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Chemically diverse multifunctional peptide platforms with antimicrobial and cell adhesive properties
dc.contributor.author | Martín Gómez, Helena |
dc.contributor.author | Oliver Cervelló, Lluís |
dc.contributor.author | Buxadera Palomero, Judit |
dc.contributor.author | Ginebra Molins, Maria Pau |
dc.contributor.author | Mas Moruno, Carlos |
dc.contributor.other | Universitat Politècnica de Catalunya. Doctorat en Ciència i Enginyeria dels Materials |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials |
dc.date.accessioned | 2021-03-01T09:02:58Z |
dc.date.available | 2021-10-23T00:28:49Z |
dc.date.issued | 2020-01-01 |
dc.identifier.citation | Martin, H. [et al.]. Chemically diverse multifunctional peptide platforms with antimicrobial and cell adhesive properties. "ChemBioChem", 2 Març 2021, vol. 21, núm. 5, p. 839-844 |
dc.identifier.issn | 1439-7633 |
dc.identifier.uri | http://hdl.handle.net/2117/340615 |
dc.description.abstract | Bacterial infections and incomplete biomaterial integration are major problems that can lead to the failure of medical implants. However, simultaneously addressing these two issues remains a challenge. Here, we present a chemical peptide library based on a multifunctional platform containing the antimicrobial peptide LF1-11 and the cell-adhesive motif RGD. The scaffolds were customized with catechol groups to ensure straightforward functionalization of the implant surface, and linkers of different length to assess the effect of peptide accessibility on the biological response. The peptidic platforms significantly improved the adhesion of mesenchymal stem cells and showed antimicrobial effects against Staphylococcus aureus. Of note is that peptides bearing spacers that were too long displayed the lowest efficiency. Subsequently, we designed a platform replacing linear RGD by cyclic RGD; this further enhanced eukaryotic cell adhesion while retaining excellent antimicrobial properties, thus being a suitable candidate for tissue engineering applications. |
dc.format.extent | 7 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials |
dc.subject.lcsh | Tissue engineering |
dc.subject.other | Antimicrobial peptides |
dc.subject.other | DOPA |
dc.subject.other | Functionalization |
dc.subject.other | Multifunctionality |
dc.subject.other | RGD motif |
dc.title | Chemically diverse multifunctional peptide platforms with antimicrobial and cell adhesive properties |
dc.type | Article |
dc.subject.lemac | Enginyeria de teixits |
dc.subject.lemac | Implants artificials -- Materials |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1002/cbic.202000670 |
dc.relation.publisherversion | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202000670 |
dc.rights.access | Open Access |
local.identifier.drac | 30583497 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Martin, H.; Oliver, L.; Buxadera-Palomero, J.; Ginebra, M.P.; Mas-Moruno, C. |
local.citation.publicationName | ChemBioChem |
local.citation.volume | 21 |
local.citation.number | 5 |
local.citation.startingPage | 839 |
local.citation.endingPage | 844 |
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