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Randomised study to assess the efficacy and safety of once-daily etravirine-based regimen as a switching strategy in HIV-infected patients receiving a protease inhibitor-containing regimen. Etraswitch study
(2014-02-04)
Article
Open AccessBackground: Etravirine (ETR) was approved for patients with virological failure and antiretroviral resistance mutations. It has also shown antiviral efficacy in antiretroviral-naive patients. However, data on the switching ... -
On left-truncating and mixing poisson distributions
(2014-02-01)
Article
Open AccessThe distributions obtained by left-truncating at k a mixed Poisson distribution, kT-MP, and those obtained by mixing previously left-truncated Poisson distributions, M-kTP, are characterized by means of their probability ... -
Young biostatisticians in Spain: career or race?
(Sociedad de Estadística e Investigación Operativa (SEIO), 2013-10)
Article
Restricted access - publisher's policyChallenges and new opportunities for the integration of biostatisticians in multidisciplinary teams are a major concern in the field. New forms of broader training in the life sciences, collaborations with other scientists, ... -
Quantile estimation of the rejection distribution of food products integrating assessor values and interval-censored consumer data
(2013-12)
Article
Restricted access - publisher's policyFitting parametric survival models with interval-censore d data is a common task in survival analysis and implemented in many statistical software pack ages. Here, we present a novel approach to fit such models if the ... -
On poisson-stopped-sums that are mixed poisson
(2013)
Article
Restricted access - publisher's policyMaceda (1948) characterized the mixed Poisson distributions that are Poisson-stopped-sum distributions based on the mixing distribution. In an alternative characterization of the same set of distributions here the ... -
Time of progression to osteopenia/osteoporosis in chronically HIV-infected patients: screening DXA scan
(2012-10-08)
Article
Open AccessAlgorithms for bone mineral density (BMD) management in HIV-infected patients are lacking. Our objective was to assess how often a dual-energy x-ray absorptiometry (DXA) scan should be performed by assessing time of ... -
BioStatNet: an interdisciplinary biostatistics network
(Sociedad de Estadística e Investigación Operativa (SEIO), 2012-06)
Article
Open AccessBiostatistics has become a major scientific component of biomedical research with a strong interdisciplinary basis. This endeavour is essentially interdisciplinary, therefore, training of future biostatisticians must ... -
Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru
(2012-06)
Article
Open AccessKnowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type ... -
Statistical considerations when using a composite endpoint for comparing treatment groups
(2012-08)
Article
Restricted access - publisher's policyWhen comparing two treatment groups in a time-to-event analysis, it is common to use a composite event consisting of two or more distinct outcomes. The goal of this paper is to develop a statistical methodology to derive ... -
Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy''): the influence of gender and genetics (CYP2D6, COMT, 5-HTT)
(2012-10-24)
Article
Open AccessThe synthetic psychostimulant MDMA (63,4-methylenedioxymethamphetamine, ecstasy) acts as an indirect serotonin, dopamine, and norepinephrine agonist and as a mechanism-based inhibitor of the cytochrome P-450 2D6 (CYP2D6). ... -
Research Letter: is neuroticism a risk factor for postpartum depression?
(2012-04-16)
Article
Open AccessAlthough the relationship between personality and depressive illness is complex (Shea, 2005), there is empirical evidence that some personality features such as neuroticism, harm avoidance, introversion, dependency, ... -
Factors associated with discharge against medical advice from an alcohol and drug inpatient detoxifcation unit in Barcelona between 1993 and 2006
(2012)
Article
Open AccessRecords from 1,228 consecutively admitted patients (74.5% male) to an inpatient detoxification unit in Barcelona between 1993 and 2006 were examined to determine factors associated with discharge against medical advice ...
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