GREMA - Grup de Recerca en Estadística Matemàtica i les seves Aplicacions

Recent Submissions

  • Extension of the asymptotic relative efficiency method to select the primary endpoint in a randomized clinical trial 

    Plana-Ripoll, Oleguer; Gómez Melis, Guadalupe (2014-10-13)
    Research report
    Open Access
    We extend the ARE method proposed in Gómez and Lagakos (2013) devised to decide which primary endpoint to choose when comparing two treatments in a randomized clinical trial. The ARE method is based on the Asymptotic ...

  • Developing professional skills at tertiary level: A model to integrate competencies across the curriculum 

    Sánchez Carracedo, Fermín; Soler Cervera, Antonia; López Álvarez, David; Martín Escofet, Carme; Ageno Pulido, Alicia; Belanche Muñoz, Luis Antonio; Cabré Garcia, José M.; Cobo Valeri, Erik; Farré Cirera, Rafael; García Almiñana, Jordi; Marès Martí, Pere (Institute of Electrical and Electronics Engineers (IEEE), 2014)
    Conference report
    Open Access
    In the context of the European Higher Education Area, curriculum design needs to be based on the defined competencies of each degree programs, including both domain specific and professional competencies. In this educational ...

  • Effect of changing the copular when choosing the primary endpoint in a Randomized Clinical Trial 

    Plana Ripoll, Oleguer; Gómez Melis, Guadalupe (2013)
    Conference report
    Open Access

  • Randomised study to assess the efficacy and safety of once-daily etravirine-based regimen as a switching strategy in HIV-infected patients receiving a protease inhibitor-containing regimen. Etraswitch study 

    Echeverria, Patricia; Bonjoch, Anna; Puig Batalla, Jorge; Molto, Jose; Paredes, Roger; Sirera, Guillem; Ornelas, Arelly; Pérez Álvarez, Nuria; Clotet, Bonaventura; Negredo, Eugènia (2014-02-04)
    Article
    Open Access
    Background: Etravirine (ETR) was approved for patients with virological failure and antiretroviral resistance mutations. It has also shown antiviral efficacy in antiretroviral-naive patients. However, data on the switching ...

  • Some theoretical thoughts when using a composite endpoint to prove the efficacy of a treatment 

    Gómez Melis, Guadalupe (2011)
    Conference report
    Open Access
    This paper discusses, following Gómez and Lagakos (2011) methodology, to what extent is there a gain in efficiency from adding a component event to a relevant endpoint when the treatment effect on this component is not as ...

  • On left-truncating and mixing poisson distributions 

    Valero Baya, Jordi; Pérez Casany, Marta; Ginebra Molins, Josep (2014-02-01)
    Article
    Open Access
    The distributions obtained by left-truncating at k a mixed Poisson distribution, kT-MP, and those obtained by mixing previously left-truncated Poisson distributions, M-kTP, are characterized by means of their probability ...

  • Review of multivariate survival data 

    Gómez Melis, Guadalupe; Calle Rosingana, M. Luz; Serrat Piè, Carles; Espinal Berenguer, Anna (2004-09)
    Research report
    Open Access
    This paper reviews some of the main contributions in the area of multivariate survival data and proposes some possible extensions. In particular, we have concentrated our search and study on those papers that are relevant ...

  • Joint modelling analysis of prostate cancer incidence: frequentist and bayesian approaches 

    Piulachs Lozada Benavente, Xavier; Serrat Piè, Carles; Rué, Montserrat; Armero, Carmen; Forte, Anabel; Perpiñán, Héctor; Luján, Marcos; Páez, Álvaro (2013)
    Conference lecture
    Open Access
    Prostate specific antigen (PSA) is a biomarker for prostate cancer (PCa) that is widely used for PCa screening. Using a database of 2415 men included in the Spanish screening arm of the ERSPC Study, we will use joint ...

  • Estimation of survival functions subject to order restrictions 

    Serrat Piè, Carles; Moreno, Laura (Universitat Oberta de Catalunya, 2013)
    Conference lecture
    Open Access
    This contribution is framed in, and is part of, the Durabiltiy of Building Facades studies carried out in the last decade in the Institut d’Estadística i Matemàtica Aplicada a l’Edificació and Laboratori d’ Edificació at ...

  • Longitudinal + reliability = joint modeling 

    Serrat Piè, Carles (2013)
    Conference lecture
    Open Access
    The aim of this presentation is to introduce joint modelling techniques for the simultaneous analysis of longitudinal time-varying data and time-to-event data. This is an increasing area of interest for the analysis of ...

  • Recommendations to choose the primary endpoint in cardiovascular clinical trials 

    Gómez Melis, Guadalupe; Gómez Mateu, Moisés; Dafni, Urania (2013)
    Research report
    Open Access
    Background – A composite endpoint is often used as the primary endpoint to assess the efficacy of a new treatment in randomized clinical trials (RCT). In cardiovascular trials, the often rare event of the relevant primary ...

  • Young biostatisticians in Spain: career or race? 

    Lorenzo Arribas, Altea; Martínez Silva, Isabel; Gómez Mateu, Moisés; Pérez Álvarez, Nuria; Perpiñán Fabuel, Hèctor; Valero Coppin, Oliver (Sociedad de Estadística e Investigación Operativa (SEIO), 2013-10)
    Article
    Restricted access - publisher's policy
    Challenges and new opportunities for the integration of biostatisticians in multidisciplinary teams are a major concern in the field. New forms of broader training in the life sciences, collaborations with other scientists, ...

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