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dc.contributorTzanov, Tzanko
dc.contributorGuaus Guerrero, Ester
dc.contributorIvanova, Kristina Dimitrova
dc.contributor.authorVitucci, Sofia
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2021-02-03T09:36:21Z
dc.date.available2021-02-03T09:36:21Z
dc.date.issued2020-10-28
dc.identifier.urihttp://hdl.handle.net/2117/336770
dc.description.abstractContact lenses (CLs) are medical devices widely used for vision correction, cosmetic or therapeutic reasons. CLs are ideal surface for bacteria to adhere and establish antibiotic resistant biofilms, being the Pseudomonas aeruginosa (P. aeruginosa) the most frequently isolated bacterial pathogen causing CLs-associated microbial keratitis. Their use also introduces numerous factors (e.g. patient compliance and hand hygiene) that increase the ability of bacteria to interact with the cornea and cause difficult to treat infections. In the present study, a hybrid nanocomposite coating of antimicrobial silver-Cruox nanoparticles (AgCru NPs), anti-fouling poly(sulfobetaine methacrylate) (pSBMA) and biofilm-matrix degrading enzyme a-Amylase has been developed onto silicone hydrogel CLs in a one-step sonochemical process to impart antibacterial and antibiofilm functionalities. Hybrid AgCru NPs with antibacterial activity against P. aeruginosa have been produced in a green synthetic approach using Cruox - a bio-liquefied wheat bran containing ferulic acid, di-ferulic acids and arabinoxylans - as both reducing and capping agent. Coating the CLs with hybrid NPs under high intensity ultrasound did not alter their refractive properties and water content. Moreover, the CLs´ functionalization led to improved wettability compared to the pristine CLs and demonstrated strong capacity to reduce the growth and biofilm formation of P. aeruginosa by 6.4 and 1.7 Log (CFU/mL), respectively. The novel nanocomposite coatings were biocompatible to human cells and as a such are of great potential to prevent CLs-wearing associated bacterial infections
dc.language.isoeng
dc.publisherUniversitat Politècnica de Catalunya
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la visió::Contactologia
dc.subject.lcshContact lenses
dc.subject.lcshNanoparticles
dc.titleAntibacterial hybrid nanoparticles coating for inhibition of bacterial growth and biofilm formation
dc.typeMaster thesis
dc.subject.lemacLents de contacte
dc.subject.lemacLents de contacte -- Microbiologia
dc.subject.lemacNanopartícules
dc.identifier.slugPRISMA-151822
dc.rights.accessOpen Access
dc.date.updated2020-12-01T12:53:17Z
dc.audience.educationlevelMàster
dc.audience.mediatorFacultat d'Òptica i Optometria de Terrassa
dc.audience.degreeMÀSTER UNIVERSITARI EN OPTOMETRIA I CIÈNCIES DE LA VISIÓ (Pla 2012)


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain