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Cording mycobacterium tuberculosis bacilli have a key role in the progression towards active tuberculosis, which is stopped by previous immune response

dc.contributor.authorArias, Lilibeth
dc.contributor.authorCardona, Paula
dc.contributor.authorCatalà Sabaté, Martí
dc.contributor.authorPrats Soler, Clara
dc.contributor.authorVilaplana, Cristina
dc.contributor.authorCardona Iglesias, Pere Joan
dc.contributor.authorJulian Gómez, Esther
dc.contributor.authorCampo Pérez, Víctor
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Física Computacional i Aplicada
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2020-12-21T11:08:59Z
dc.date.available2020-12-21T11:08:59Z
dc.date.issued2020-02-08
dc.identifier.citationArias, L. [et al.]. Cording mycobacterium tuberculosis bacilli have a key role in the progression towards active tuberculosis, which is stopped by previous immune response. "Microorganisms", 8 Febrer 2020, vol. 8, núm. 228, p. 1-14.
dc.identifier.issn2076-2607
dc.identifier.urihttp://hdl.handle.net/2117/334710
dc.description.abstractCording was the first virulence factor identified in Mycobacterium tuberculosis (Mtb). We aimed to ascertain its role in the induction of active tuberculosis (TB) in the mouse strain C3HeB/FeJ by testing the immunopathogenic capacity of the H37Rv strain. We have obtained two batches of the same strain by stopping their growth in Proskauer Beck liquid medium once the mid-log phase was reached, in the noncording Mtb (NCMtb) batch, and two days later in the cording Mtb (CMtb) batch, when cording could be detected by microscopic analysis.
dc.description.sponsorshipThis work was supported by the European Commission Horizon 2020 research and innovation program under grant agreement TBVAC2020 No. 643381 and la Caixa Foundation (ID 100010434), under agreement LCF/PR/GN16/10290002. The Experimental Tuberculosis Unit is accredited by the Catalan Agency for Management of University and Research Grants (AGAUR) with code 2017 SGR500 and the IGTP is a member of the CERCA network of institutes. This work was supported by the Plan Nacional I + D + I co-financed by ISCIII-Subdirección General de Evaluación and Fondo-EU de Desarrollo Regional (FEDER) through CV contract CPII18/00031 and PC contract IFI14/00015. EJ was supported by the AGAUR-Generalitat de Catalunya (2017SGR-0229) grant. VC-P is recipient of a pre-doctoral contract from the AGAUR-Generalitat de Catalunya (FI).
dc.format.extent14 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Modelització matemàtica
dc.subject.lcshMycobacterium tuberculosis
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherCording
dc.subject.otherC3HeB/FeJ mice
dc.subject.otherNeutrophils
dc.subject.otherBCG
dc.subject.otherCXCL-1
dc.subject.otherNeutrophilic extracellular traps
dc.titleCording mycobacterium tuberculosis bacilli have a key role in the progression towards active tuberculosis, which is stopped by previous immune response
dc.typeArticle
dc.subject.lemacTuberculosi -- Epidemiologia
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
dc.identifier.doi10.3390/microorganisms8020228
dc.relation.publisherversionhttps://www.mdpi.com/2076-2607/8/2/228
dc.rights.accessOpen Access
local.identifier.drac26907003
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/643381/EU/TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development/TBVAC2020
dc.relation.projectid00015
local.citation.authorArias, L.; Cardona, P.; Català, M.; Prats, C.; Vilaplana, C.; Cardona, P.J.; Julian, E.; Campo, V.
local.citation.publicationNameMicroorganisms
local.citation.volume8
local.citation.number228
local.citation.startingPage1
local.citation.endingPage14


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Attribution-NonCommercial-NoDerivs 3.0 Spain
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