A combined approach of numerical simulation and additive manifacturing technique for in-silico and in-vitro testing of a 3d printing-based aortic polymeric heart valve
Visualitza/Obre
Estadístiques de LA Referencia / Recolecta
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/334294
Tipus de documentText en actes de congrés
Data publicació2019
EditorCIMNE
Condicions d'accésAccés obert
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Abstract
Heart valve diseases are among the leading causes of cardiac failure around the globe.
Current advances in imaging technology, in numerical simulation and in additive manufacturing
are opening new frontiers in the field of development of new personalised prosthetic devices.
The 3D printing technique could allow the realisation of personalised models for each patient
undergoing valve replacement surgery. A CAD model of an aortic valve prosthesis was designed
on the basis of elliptic-hyperboloid formulation. The resulting CAD model was used both
to perform numerical in-silico simulation and to design a modular mould for AV fabrication.
Simulations were performed through a novel hybrid approach based on RBF mesh morphing
technique and CFD simulations. The polymeric aortic valve was manufactured by 3D printed
process and spray deposition technique. To assess the in-vitro valve properties, the prototype
was inserted in a custom mock circulatory loop to reproduce the aortic flow conditions. The
manufacturing process of both the mould and the valve was successful and the in-vitro testing
showed an effective orifice area (2.5 mm2) and regurgitation fraction (5%) in accordance with
the ISO-5840-2. The novel simulation strategies have revealed to be a promising approach to
test both structural and functional device performances.
CitacióGasparotti, E. [et al.]. A combined approach of numerical simulation and additive manifacturing technique for in-silico and in-vitro testing of a 3d printing-based aortic polymeric heart valve. A: Sim-AM 2019. "Sim-AM 2019 : II International Conference on Simulation for Additive Manufacturing". CIMNE, 2019, p. 19-30. ISBN 978-84-949194-8-0.
ISBN978-84-949194-8-0
Fitxers | Descripció | Mida | Format | Visualitza |
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Sm_AM-2019_01-A COMBINED APPROACH OF NUMERICAL.pdf | 1,745Mb | Visualitza/Obre |