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dc.contributor.authorRodríguez Molinero, Alejandro
dc.contributor.authorPérez López, Carlos
dc.contributor.authorGálvez Barrón, César Pavel
dc.contributor.authorMiñarro Alonso, Antonio
dc.contributor.authorMacho Pérez, Oscar
dc.contributor.authorLópez, Gabriela F.
dc.contributor.authorRobles, María Teresa
dc.contributor.authorDapena, María Dolores
dc.contributor.authorMartínez, Sergi
dc.contributor.authorRodríguez, Ezequiel
dc.contributor.authorCollado, Isabel
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.date.accessioned2020-12-03T11:40:52Z
dc.date.available2020-12-03T11:40:52Z
dc.date.issued2020-09-03
dc.identifier.citationRodríguez, A. [et al.]. Observational study of azithromycin in hospitalized patients with COVID-19. "PloS one", 3 Setembre 2020, vol. 15, núm. 9, p. e0238681:1-e0238681:13.
dc.identifier.issn1932-6203
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470304/
dc.identifier.urihttp://hdl.handle.net/2117/333850
dc.description.abstractBACKGROUND: The rapid spread of the disease caused by the novel SARS-CoV-2 virus has led to the use of multiple therapeutic agents whose efficacy has not been previously demonstrated. The objective of this study was to analyze whether there is an association between the use of azithromycin and the evolution of the pulmonary disease or the time to discharge, in patients hospitalized with COVID-19. METHODS: This was an observational study on a cohort of 418 patients admitted to three regional hospitals in Catalonia, Spain. As primary outcomes, we studied the evolution of SAFI ratio (oxygen saturation/fraction of inspired oxygen) in the first 48 hours of treatment and the time to discharge. The results were compared between patients treated and untreated with the study drug through subcohort analyses matched for multiple clinical and prognostic factors, as well as through analysis of non-matched subcohorts, using Cox multivariate models adjusted for prognostic factors. RESULTS: There were 239 patients treated with azithromycin. Of these, 29 patients treated with azithromycin could be matched with an equivalent number of control patients. In the analysis of these matched subcohorts, SAFI at 48h had no significant changes associated to the use of azithromycin, though azithromycin treatment was associated with a longer time to discharge (10.0 days vs 6.7 days; log rank: p = 0.039). However, in the unmatched cohorts, the increased hospital stay associated to azithromycin use, was no significant after adjustment using Multivariate Cox regression models: hazard ratio 1.45 (IC95%: 0.88–2.41; p = 0.150). This study is limited by its small sample size and its observational nature; despite the strong pairing of the matched subcohorts and the adjustment of the Cox regression for multiple factors, the results may be affected by residual confusion. CONCLUSIONS: We did not find a clinical benefit associated with the use of azithromycin, in terms of lung function 48 hours after treatment or length of hospital stay.
dc.language.isoeng
dc.publisherPublic Library of Science (PLOS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina
dc.subject.lcshDrugs
dc.subject.lcshCOVID-19 (Disease)
dc.titleObservational study of azithromycin in hospitalized patients with COVID-19
dc.typeArticle
dc.subject.lemacMedicaments
dc.subject.lemacCOVID-19 (Malaltia)
dc.identifier.doi10.1371/journal.pone.0238681
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238681
dc.rights.accessOpen Access
local.identifier.drac29884792
dc.description.versionPostprint (published version)
local.citation.authorRodríguez, A.; Perez, C.; Gálvez, C.; Miñarro Alonso, Antonio; Macho, O.; López, G.; Robles, M.; Dapena, M.; Martínez, S.; Rodríguez, E.; Collado, I.
local.citation.publicationNamePloS one
local.citation.volume15
local.citation.number9
local.citation.startingPagee0238681:1
local.citation.endingPagee0238681:13


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