Numerical modelling and analysis of pore architecture in bone regeneration scaffolds
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Estadístiques de LA Referencia / Recolecta
Inclou dades d'ús des de 2022
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hdl:2117/332215
Tipus de documentProjecte Final de Màster Oficial
Data2020-06
Condicions d'accésAccés obert
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Bone regeneration constitutes a major field within tissue engineering and it is receiving widespread attention.
Bone fractures are often difficult to heal. Traditional repair methods usually yield unsatisfactory results.
One of the most recent techniques are the so-called scaffolds.
These scaffolds are small porous pieces made of Calcium Phosphate.
Once inserted in the bone fracture, they foster bone formation by, among other things, releasing Ca2+ ions.
Pore geometry is believed to play a crucial role by helping to retain the ions in the scaffold.
Therefore, determining the optimal pore geometry is key for a standardized production of scaffolds through, for example, 3D printing.
Numerical simulation offers the possibility to test different designs at a very low cost.
A numerical model that would be able to reproduce the behaviour of the scaffolds would be a very powerful tool.
In this thesis, we have put forward a simple model to reproduce the evolution of the concentration.
Using the advection-diffusion equation we have modelled the evolution of Ca2+ ions in two different scaffolds: a foam scaffold (random structure and difficult to produce)and 3D printed scaffold (ordered structure and easy to produce).
The performance of these scaffolds was tested in vivo by Barba et al. (2018).
The simulations that we have performed seem to match the experimental results: higher concentrations appear in the foam scaffold.
Additionally, we have tested the evolution of the concentration under three different velocity fields.
For the foam scaffold, the best results are obtained with a simple uniaxial flow, normal to one of the faces of the scaffold.
As for the 3D scaffold, the highest concentration is obtained with two orthogonal flows and normal to the faces.
The implementation of the equation has been done using FEniCS, an open-source platform to solve PDEs.
MatèriesNumerical analysis, Three-dimensional display systems, Anàlisi numèrica, Visualització tridimensional (Informàtica)
TitulacióMÀSTER UNIVERSITARI EN ENGINYERIA DE CAMINS, CANALS I PORTS (Pla 2012)
Fitxers | Descripció | Mida | Format | Visualitza |
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CalvetLitzell_TFM.pdf | 12,69Mb | Visualitza/Obre |