Show simple item record

dc.contributor.authorSerrancolí, Gil
dc.contributor.authorKinney, Allison
dc.contributor.authorFregly, Benjamin Jon
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Mecànica
dc.date.accessioned2020-11-12T14:29:59Z
dc.date.issued2020-11-18
dc.identifier.citationSerrancoli, G.; Kinney, A.; Fregly, B.J. Influence of musculoskeletal model parameter values on prediction of accurate knee contact forces during walking. "Medical engineering and physics", 18 Novembre 2020, vol. 85, p. 35-47.
dc.identifier.issn1350-4533
dc.identifier.urihttp://hdl.handle.net/2117/332061
dc.description.abstractTreatment design for musculoskeletal disorders using in silico patient-specific dynamic simulations is becoming a clinical possibility. However, these simulations are sensitive to model parameter values that are difficult to measure experimentally, and the influence of uncertainties in these parameter values on the accuracy of estimated knee contact forces remains unknown. This study evaluates which musculoskeletal model parameters have the greatest influence on estimating accurate knee contact forces during walking. We performed the evaluation using a two-level optimization algorithm where musculoskeletal model parameter values were adjusted in the outer level and muscle activations were estimated in the inner level. We tested the algorithm with different sets of design variables (combinations of optimal muscle fiber lengths, tendon slack lengths, and muscle moment arm offsets) resulting in nine different optimization problems. The most accurate lateral knee contact force predictions were obtained when tendon slack lengths and moment arm offsets were adjusted simultaneously, and the most accurate medial knee contact force estimations were obtained when all three types of parameters were adjusted together. Inclusion of moment arm offsets as design variables was more important than including either tendon slack lengths or optimal muscle fiber lengths alone to obtain accurate medial and lateral knee contact force predictions. These results provide guidance on which musculoskeletal model parameter values should be calibrated when seeking to predict in vivo knee contact forces accurately.
dc.format.extent13 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Biomecànica
dc.subject.lcshBiomechanics
dc.subject.otherMuscle-tendon model parameters
dc.subject.otherMuscle force estimation
dc.subject.otherKnee contact force prediction
dc.subject.otherMusculoskeletal modeling
dc.titleInfluence of musculoskeletal model parameter values on prediction of accurate knee contact forces during walking
dc.typeArticle
dc.subject.lemacBiomecànica
dc.contributor.groupUniversitat Politècnica de Catalunya. LAM - Laboratori d'Aplicacions Multimèdia i TIC
dc.identifier.doi10.1016/j.medengphy.2020.09.004
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S1350453320301375
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac29464080
dc.description.versionPostprint (updated version)
dc.date.lift2021-11-30
local.citation.authorSerrancoli, G.; Kinney, A.; Fregly, B.J.
local.citation.publicationNameMedical engineering and physics
local.citation.volume85
local.citation.startingPage35
local.citation.endingPage47


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain