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The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

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10.1126/science.aba2644
 
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hdl:2117/331106

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Venturini, Valeria
Pezzano, Fabio
Català Castro, Frederic
Häkkinen, Hanna-Maria
Jiménez-Delgado, Senda
Colomer Rosell, Mariona
Marro, Monica
Tolosa-Ramon, Queralt
Paz-López, Sonia
Valverde, Miguel A.
Weghuber, Julian
Loza- Alvarez, Pablo
Krieg, Michael
Wieser, Stefan
Ruprecht, Verena
Document typeArticle
Defense date2020-10-16
PublisherACS
Rights accessOpen Access
Attribution 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution 3.0 Spain
ProjectICFOstepstone - ICFOstepstone PhD Programme for Early-Stage Researchers in Photonics (EC-H2020-665884)
PAPEL DE LOS CANALES MECANO%2FOSMOSENSIBLES EN LAS FUNCIONES CELULARES A CORTO Y LARGO PLAZO (AEI-RTI2018-099718-B-I00)
AGR-INSTITUTO DE CIENCIAS FOTONICAS (MINECO-SEV-2015-0522)
LASERLAB-EUROPE - The Integrated Initiative of European Laser Research Infrastructures (EC-H2020-654148)
RYC-2015-17935 (MINECO-RYC-2015-17935)
DESCIFRANDO EL IMPACTO DEL ESTRES MECANICO EN LA FUNCION NEURONAL A NIVEL MOLECULAR Y DE SISTEMAS (AEI-PGC2018-097882-A-I00)
MechanoSystems - How to build a brain? Engineering molecular systems for mechanosensation and -protection in neurons (EC-H2020-715243)
CONTROL MECANOSENSIBLE DE LA TRANSFORMACION CELULAR A LA MOTILIDAD EN ENTORNOS 3D (AEI-BFU2017-86296-P)
Abstract
Single cells continuously experience and react to mechanical challenges in three-dimensional tissues. Spatial constraints in dense tissues, physical activity, and injury all impose changes in cell shape. How cells can measure shape deformations to ensure correct tissue development and homeostasis remains largely unknown (see the Perspective by Shen and Niethammer). Working independently, Venturini et al. and Lomakin et al. now show that the nucleus can act as an intracellular ruler to measure cellular shape variations. The nuclear envelope provides a gauge of cell deformation and activates a mechanotransduction pathway that controls actomyosin contractility and migration plasticity. The cell nucleus thereby allows cells to adapt their behavior to the local tissue microenvironment.
CitationVenturini, V. [et al.]. The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior. "Science", 16 Octubre 2020, vol. 370, núm. 6514, p. eaba2644. 
URIhttp://hdl.handle.net/2117/331106
DOI10.1126/science.aba2644
Publisher versionhttps://science.sciencemag.org/content/370/6514/eaba2644.full
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