Technological and evolutionary challenges for reconstructing our ancestor’s genome from 500 million years ago
Tipus de documentText en actes de congrés
Data publicació2020
EditorBarcelona Supercomputing Center
Condicions d'accésAccés obert
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Abstract
It was long known that our genome harbors redundant components, which was introduced
by the so-called two-round whole genome duplications (2R-WGD). In 2009, the
speaker of this seminar proposed for the first time that the 2R-WGD occurred before
the evolutionary lineage of cyclostomes (hagfishes and lampreys) branched off from the
future jawed vertebrate lineage (Kuraku et al., 2009. Mol. Evol. Biol. 26:47-; ‘PV4 hypothesis’).
Since then, the genome sequence information of cyclostomes (mainly northern
hemisphere lampreys) has been repeatedly analyzed, which however has not resulted
in synthetic understanding that reconciles different aspects of their genomes including
multiplicity of landmark gene clusters (e.g. Hox gene clusters) and phylogenetic properties
of paralogous genes. Most recently, the speaker’s research group performed whole genome sequencing and molecular evolutionary analysis of elasmobranch sharks
(Hara et al., 2018. Nat. Ecol. Evol. 2:1761-). These genomes exhibit remarkably lesser
degrees of sequence divergence and thus highlight a derived nature of cyclostome
genomes (reviewed in Manousaki et al., 2016.). This seminar will summarize the history
of studies on the 2R-WGD and discuss potential solutions for disentangling it (see Onimaru
& Kuraku, 2018. Brief. Funct. Genomics 17:352-).
CitacióKuraku, S. Technological and evolutionary challenges for reconstructing our ancestor's genome from 500 million years ago. A: . Barcelona Supercomputing Center, 2020, p. 37-38.
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