A computational model for the cooperative binding and self-organization of Myosin-VI in membrane reshaping

Abstract

The dynamic membrane reshaping processes are vital for the cells to preform its activity normally. They are involved in a myriad of cellular pathways and can be preformed by different agents. One of those is the myosin-VI, one of the motor proteins that produce the force that will move the membrane. To do that the protein binds to the membrane, this binding has been seen to be targeted towards specific regions of the membrane. In this project a model for the cooperative binding of the myosin VI and a membrane pore will be developed. The growth of the pore will produce a partial derivative equation with moving boundaries that will be solved numerically utilizing the Boundary element method. Then the model will be validated by comparing it to experimental data.