Multilevel passive microfluidics for electrochemical biosensors

Abstract

Herein, we present a proof-of-concept 3D (multilevel) passive microfluidic device for point-of-care applications including electrochemical biosensors. Multiphase flow (air-water interface) within multilevel microchannels has been evaluated using 3D numerical simulations. The design was based on a pre-programmed sequence of fluids (biofluids and electrolytes) on the surface of a biosensor using trigger valves and microchannel resistances. Flow was driven uniquely by the surface tension and the capillary force triggered by the introduction of the sample without any external microfluidic equipment