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dc.contributor.authorSachot, Nadège
dc.contributor.authorCastaño Linares, Óscar
dc.contributor.authorPlanell Estany, Josep Anton
dc.contributor.authorEngel López, Elisabeth
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2020-10-01T07:40:08Z
dc.date.available2020-10-01T07:40:08Z
dc.date.issued2015-08-01
dc.identifier.citationSachot, N. [et al.]. Optimization of blend parameters for the fabrication of polycaprolactone-silicon based ormoglass nanofibers by electrospinning. "Journal of biomedical materials research. Part B, Applied biomaterials", 1 Agost 2015, vol. 103, núm. 6, p. 1287-1293.
dc.identifier.issn1552-4973
dc.identifier.urihttp://hdl.handle.net/2117/329589
dc.description.abstractElectrospinning is a method that can be used to efficiently produce scaffolds that mimic the fibrous structure of natural tissue, such as muscle structures or the extracellular matrix of bone. The technique is often used as a way of depositing composites (organic/inorganic materials) to obtain bioactive nanofibers which have the requisite mechanical properties for use in tissue engineering. However, many factors can influence the formation and collection of fibers, including experimental variables such as the parameters of the solution of the electrospun slurry. In this study, we assessed the influence of the polymer concentration, glass content and glass hydrolysis level on the morphology and thickness of fibers produced by electrospinning for a PCL-(Si-Ca-P-2) bioactive ormoglassorganically modified glassblend. Based on previous assays, this combination of materials shows good angiogenic and osteogenic properties, which gives it great potential for use in tissue engineering. The results of our study showed that blend preparation directly affected the features of the resulting fibers, and when the parameters of the blend are precisely controlled, fibers with a regular diameter could be produced fairly easily when 2,2,2-trifluoroethanol was used as a solvent instead of tetrahydrofuran. The diameter of the homogeneous fibers ranged from 360 to 620 nm depending on the experimental conditions used. This demonstrates that experimental optimization of the electrospinning process is crucial in order to obtain a deposit of hybrid nanofibers with a regular shape. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1287-1293, 2015.
dc.format.extent7 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshBiomedical materials
dc.subject.lcshElectrospinning
dc.subject.otherSi-based glasses
dc.subject.otherormoglass
dc.subject.otherelectrospinning
dc.subject.otherhybrid materials
dc.subject.otherbioactivity
dc.subject.otherangiogenesis
dc.subject.othertissue regeneration
dc.subject.otherbone regeneration
dc.subject.otherscaffolds
dc.subject.otherpolymer
dc.subject.otherfibers
dc.subject.otherglass
dc.subject.othermorphology
dc.subject.otherjets
dc.subject.othercell
dc.subject.otherdiameter
dc.titleOptimization of blend parameters for the fabrication of polycaprolactone-silicon based ormoglass nanofibers by electrospinning
dc.typeArticle
dc.subject.lemacMaterials biomèdics
dc.subject.lemacElectrofilatura
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.identifier.doi10.1002/jbm.b.33306
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33306/abstract;jsessionid=68DE5216036DFB76CFABAF52B158139E.f04t03
dc.rights.accessOpen Access
local.identifier.drac16843523
dc.description.versionPostprint (author's final draft)
local.citation.authorSachot, N.; Castaño, O.; Planell, J. A.; Engel, E.
local.citation.publicationNameJournal of biomedical materials research. Part B, Applied biomaterials
local.citation.volume103
local.citation.number6
local.citation.startingPage1287
local.citation.endingPage1293


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain