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Biological responses of ceramic bone spacers produced by green processing of additively manufactured thin meshes

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Artícle tal com està penjat a la web d'MDPI (2,796Mb)
 
10.3390/ma13112497
 
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Cita com:
hdl:2117/328461

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Minguella Canela, JoaquimMés informacióMés informacióMés informació
Calero, José Antonio
Korkusuz, Feza
Korkusuz, Petek
Kankiliç, Berna
Bilgiç, Elif
Santos López, M. Antonia de losMés informacióMés informacióMés informació
Document typeArticle
Defense date2020-05-30
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Rights accessOpen Access
Attribution 4.0 International
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution 4.0 International
Abstract
Bone spacers are exclusively used for replacing the tissue after trauma and/or diseases. Ceramic materials bring positive opportunities to enhance greater osteointegration and performance of implants, yet processing of porous geometries can be challenging. Additive Manufacturing (AM) opens opportunities to grade porosity levels in a part; however, its productivity may be low due to its batch processing approach. The paper studies the biological responses yielded by hydroxyapatite with ß-TCP (tricalcium phosphate) ceramic porous bone spacers manufactured by robocasting 2-layer meshes that are rolled in green and sintered. The implants are assessed in vitro and in vivo for their compatibility. Human bone marrow mesenchymal stem cells attached, proliferated and differentiated on the bone spacers produced. Cells on the spacers presented alkaline phosphatase staining, confirming osteogenic differentiation. They also expressed bone-specific COL1A1, BGAP, BSP, and SPP1 genes. The fold change of these genes ranged between 8 to 16 folds compared to controls. When implanted into the subcutaneous tissue of rabbits, they triggered collagen fibre formation and mild fibroblastic proliferation. In conclusion, rolled AM-meshes bone spacers stimulated bone formation in vitro and were biocompatible in vivo. This technology may give the advantage to custom produce spacers at high production rates if industrially upscaled.
CitationMinguella-Canela, J. [et al.]. Biological responses of ceramic bone spacers produced by green processing of additively manufactured thin meshes. "Materials", 30 Maig 2020, vol. 13, núm. 11, p. 2497:1-2497:13. 
URIhttp://hdl.handle.net/2117/328461
DOI10.3390/ma13112497
ISSN1996-1944
Publisher versionhttps://www.mdpi.com/1996-1944/13/11/2497
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