BBT - Biomaterials, Biomecànica i Enginyeria de Teixits

 

El Grup de Biomaterials, Bioemecànica i Enginyeria de Teixits basa la seva recerca en el desenvolupament de biomaterials per a la regeneració i/o la reparació funcional de teixits i òrgans. Això comprèn el disseny de materials capaços de modular la resposta biològica del teixit receptor, donant lloc en alguns casos a la regeneració de teixits, i en altres a una perfecta integració del biomaterial, amb la recuperació funcional perduda.
El plantejament d'aquest objectiu és intrínsecament interdisciplinari, i exigeix d’una banda la caracterització dels materials a nivell físicoquímic i mecànic i, de l'altra, l'estudi de les seves interaccions amb les entitats biològiques a diferents nivells -proteïnes, cèl·lules i teixits-.
La recerca duta a terme pel grup BBT abasta tant aspectes fonamentals com d'altres més tecnològics, susceptibles de ser transferits a empreses del sector biomèdic.

El Grupo de Biomateriales, Biomecánica e Ingeniería de Tejidos basa su investigación en el desarrollo de biomateriales para la regeneración y / o la reparación funcional de tejidos y órganos. Esto comprende el diseño de materiales capaces de modular la respuesta biológica del tejido receptor, dando lugar en algunos casos a la regeneración de tejidos, y en otros a una perfecta integración del biomaterial, con la recuperación funcional perdida. El planteamiento de este objetivo es intrínsecamente interdisciplinario, y exige por un lado la caracterización de los materiales a nivel físico-químico y mecánico y, por otro, el estudio de sus interacciones con las entidades biológicas a diferentes niveles -proteínas, celulas y tejidos-.La investigación llevada a cabo por el grupo BBT abarca tanto aspectos fundamentales como otros más tecnológicos, susceptibles de ser transferidos a empresas del sector biomédico.

The Biomaterials, Biomechanics and Tissue Engineering Group carries out research into the development of biomaterials for the regeneration and/or functional repair of tissues and organs. There is a demand for the design of materials that are able to modulate the biological response of receiving tissues. In some cases this ability leads to the regeneration and neoformation of degraded tissue, and in others, the perfect integration of the biomaterial and the recovery of the lost function.

The Biomaterials, Biomechanics and Tissue Engineering Group carries out research into the development of biomaterials for the regeneration and/or functional repair of tissues and organs. There is a demand for the design of materials that are able to modulate the biological response of receiving tissues. In some cases this ability leads to the regeneration and neoformation of degraded tissue, and in others, the perfect integration of the biomaterial and the recovery of the lost function.

Recent Submissions

  • El juego de rol como metodología activa (o cómo hacer mucho con muy poco) 

    Salán Ballesteros, Maria Núria; Rupérez de Gracia, Elisa; Llumà Fuentes, Jordi; Jorba Peiró, Jordi; Rodríguez Rius, Daniel; Torres Hernández, Yadir (Sociedad Española de Materiales, 2017)
    Article
    Open Access
    Covenantee:  Universidad de Sevilla
    Este trabajo, diseñado desde el Grupo de Innovación Docente en Materiales (GIDMat-RIMA), plantea una experiencia de innovación docente en la que el peso del proceso de aprendizaje recae, mayoritariamente, en el estudiantado, ...

  • Influence of the elastic modulus on the osseointegration of dental implants 

    Brizuela Velasco, Aritza; Herrero Climent, Mariano; Ríos Carrasco, Elisa; Rios Santos, Jose Vicente; Pérez Antoñanzas, Román; Manero Planella, José María; Gil Mur, Francisco Javier (Multidisciplinary Digital Publishing Institute (MDPI), 2019-01-01)
    Article
    Open Access
    Covenantee:  Universidad de Oviedo / Universidad de Sevilla / Universitat Internacional de Catalunya
    The load transfer from metallic prosthesis to tissue plays an important role in the success of a designed device. From a mechanical behavior point of view, the load transfer will be favored when the elastic modulus between ...

  • RE-irradiation of silver nanoparticles obtained by laser ablation in water and assessment of their antibacterial effect 

    Fernández Arias, M.; Boutinguiza Larosi, Mohamed; del Val García, Jesús; Medina, Estefanía; Rodríguez Rius, Daniel; Riveiro, A.; Comesaña Piñeiro, Rafael; Lusquiños Rodriguez, Fernando; Gil Mur, Francisco Javier; Pou Saracho, Juan María (2019-04-15)
    Article
    Restricted access - publisher's policy
    Covenantee:  Universidade de Vigo / Universitat Internacional de Catalunya
    The rapid evolution of resistant bacteria is a huge problem in medicine because makes the treatment of infections more and more difficult. The bactericidal properties of noble metal nanoparticles could be a solution. In ...

  • Pyruvate plays a main role in the antitumoral selectivity of cold atmospheric plasma in osteosarcoma 

    Tornin Cavielles, Juan; Mateu Sanz, Miguel; Rodríguez, Aida; Labay, Cédric Pierre; Rodríguez, Rene; Canal Barnils, Cristina (Nature, 2019-07-23)
    Article
    Open Access
    Covenantee:  Hospital Universitario Central de Asturias / Instituto Universitario de Oncología del Principado de Asturias / Centro de Investigación Biomédica en Red. Bioingeniería, Biomateriales y Nanomedicina
    Osteosarcoma (os) is the most common primary bone tumor but current therapies still have poor prognosis. Cold Atmospheric Plasma (CAP) and Plasma activated media (PAM) have shown potential to eliminate cancer cells in other ...

  • Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief review 

    Khlyustova, Anna; Labay, Cédric Pierre; Machala, Zdenko; Ginebra Molins, Maria Pau; Canal Barnils, Cristina (2019-06)
    Article
    Restricted access - publisher's policy
    Covenantee:  Univerzita Komenského v Bratislave / Univerzita Komenského v Bratislave
    Reactive oxygen and nitrogen species (RONS) are among the key factors in plasma medicine. They are generated by atmospheric plasmas in biological fluids, living tissues and in a variety of liquids. This ability of plasmas ...

  • Porous titanium-hydroxyapatite composite coating obtained on titanium by cold gas spray with high bond strength for biomedical applications 

    Guillem Martí, Jordi; Cinca i Luis, Núria; Punset Fuste, Miquel; Garcia Cano, Irene; Gil Mur, Francisco Javier; Guilemany Casadamon, Josep Maria; Dosta, Sergi (Elsevier, 2019-04-24)
    Article
    Restricted access - publisher's policy
    Covenantee:  Universitat de Barcelona. Departament de Ciència dels Materials i Química Física
    The lack of bioactivity of titanium (Ti) is one of the main drawbacks for its application in biomedical implants since it can considerable reduce its osseointegration capacities. One strategy to overcome this limitation ...

  • The effect of the thermosensitive biodegradable PLGA–PEG–PLGA copolymer on the rheological, structural and mechanical properties of thixotropic self-hardening tricalcium phosphate cement 

    Vojtova, Lucy; Michlovska, Lenka; Valova, Kristyna; Ginebra Molins, Maria Pau (2019-01-17)
    Article
    Open Access
    Covenantee:  Vysoké učení technické v Brně / České vysoké učení technické v Praze / Fakultní nemocnice Brno / Akademie věd České republiky
    The current limitations of calcium phosphate cements (CPCs) used in the field of bone regeneration consist of their brittleness, low injectability, disintegration in body fluids and low biodegradability. Moreover, no method ...

  • In vivo efficiency of antimicrobial inorganic bone grafts in osteomyelitis treatments 

    Mestres Beà, Gemma; Fernández Yague, Marc Antoni; Pastorino Carraz, David; Montufar Jiménez, Edgar Benjamin; Canal Barnils, Cristina; Manzanares Céspedes, Maria Cristina; Ginebra Molins, Maria Pau (Elsevier, 2019-04-01)
    Article
    Restricted access - author's decision
    Covenantee:  Uppsala universitet / Vysoké učení technické v Brně / Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut / Institut de Bioenginyeria de Catalunya / Institut d'Investigació Biomèdica de Bellvitge

  • In vitro evaluation of a multispecies oral biofilm over antibacterial coated titanium surfaces 

    Vilarrasa Sánchez, Javier; Delgado Caroña, Luis María; Galofré Mercadé, Marta; Manero Planella, José María (Springer, 2018-11-03)
    Article
    Restricted access - publisher's policy
    Peri-implantitis is an infectious disease that affects the supporting soft and hard tissues around dental implants and its prevalence is increasing considerably. The development of antibacterial strategies, such as titanium ...

  • Vertical bone regeneration with synthetic biomimetic calcium phosphate onto the calvaria of rats 

    Hoornaert, Alain; Maazouz, Yassine; Pastorino Carraz, David; Aparicio, Carlos; Ginebra Molins, Maria Pau; Layrolle, P (2019-01-18)
    Article
    Restricted access - publisher's policy
    Covenantee:  Inserm / University of Minnesota School of Dentistry
    Bone regeneration is often required to provide adequate oral rehabilitation before dental implants. Vertical ridge augmentation is the most challenging of all situations, and often requires the use of autologous bone ...

  • RGD mutation of the heparin binding II fragment of fibronectin for guiding mesenchymal stem cell behavior on titanium surfaces 

    Guillem Martí, Jordi; Gelabert París, Maria; Heras Parets, Aina; Pegueroles Neyra, Marta; Ginebra Molins, Maria Pau; Manero Planella, José María (2019-01-04)
    Article
    Restricted access - publisher's policy
    Installing bioactivity on metallic biomaterials by mimicking the extracellular matrix (ECM) is crucial for stimulating specific cellular responses to ultimately promote tissue regeneration. Fibronectin is an ECM protein ...

  • The influence of physicochemical properties of biomimetic Hydroxyapatite on the in vitro behavior of endothelial progenitor cells and their interaction with mesenchymal stem cells 

    Sadowska, Joanna Maria; Guillem Martí, Jordi; Ginebra Molins, Maria Pau (2018-12-05)
    Article
    Open Access
    Calcium phosphate (CaP) substrates are successfully used as bone grafts due to their osteogenic properties. However, the influence of the physicochemical features of CaPs in angiogenesis is frequently neglected despite it ...

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