BBT - Biomaterials, Biomecànica i Enginyeria de Teixits

 

El Grup de Biomaterials, Bioemecànica i Enginyeria de Teixits basa la seva recerca en el desenvolupament de biomaterials per a la regeneració i/o la reparació funcional de teixits i òrgans. Això comprèn el disseny de materials capaços de modular la resposta biològica del teixit receptor, donant lloc en alguns casos a la regeneració de teixits, i en altres a una perfecta integració del biomaterial, amb la recuperació funcional perduda.
El plantejament d'aquest objectiu és intrínsecament interdisciplinari, i exigeix d’una banda la caracterització dels materials a nivell físicoquímic i mecànic i, de l'altra, l'estudi de les seves interaccions amb les entitats biològiques a diferents nivells -proteïnes, cèl·lules i teixits-.
La recerca duta a terme pel grup BBT abasta tant aspectes fonamentals com d'altres més tecnològics, susceptibles de ser transferits a empreses del sector biomèdic.

El Grupo de Biomateriales, Biomecánica e Ingeniería de Tejidos basa su investigación en el desarrollo de biomateriales para la regeneración y / o la reparación funcional de tejidos y órganos. Esto comprende el diseño de materiales capaces de modular la respuesta biológica del tejido receptor, dando lugar en algunos casos a la regeneración de tejidos, y en otros a una perfecta integración del biomaterial, con la recuperación funcional perdida. El planteamiento de este objetivo es intrínsecamente interdisciplinario, y exige por un lado la caracterización de los materiales a nivel físico-químico y mecánico y, por otro, el estudio de sus interacciones con las entidades biológicas a diferentes niveles -proteínas, celulas y tejidos-.La investigación llevada a cabo por el grupo BBT abarca tanto aspectos fundamentales como otros más tecnológicos, susceptibles de ser transferidos a empresas del sector biomédico.

The Biomaterials, Biomechanics and Tissue Engineering Group carries out research into the development of biomaterials for the regeneration and/or functional repair of tissues and organs. There is a demand for the design of materials that are able to modulate the biological response of receiving tissues. In some cases this ability leads to the regeneration and neoformation of degraded tissue, and in others, the perfect integration of the biomaterial and the recovery of the lost function.

The Biomaterials, Biomechanics and Tissue Engineering Group carries out research into the development of biomaterials for the regeneration and/or functional repair of tissues and organs. There is a demand for the design of materials that are able to modulate the biological response of receiving tissues. In some cases this ability leads to the regeneration and neoformation of degraded tissue, and in others, the perfect integration of the biomaterial and the recovery of the lost function.

Recent Submissions

  • New trends in the development of multifunctional peptides to functionalize biomaterials 

    Oliver-Cervelló, Lluís; Martín Gómez, Helena; Mas Moruno, Carlos (2021-05-24)
    Article
    Open Access
    Improving cell-material interactions is a major goal in tissue engineering. In thisregard, functionalization of biomaterials with cell instructive molecules from theextracellular matrix stands out as a powerful strategy ...

  • Analysis of the Jahn-Teller effect in coronene and corannulene ions and its effect in EPR spectroscopy 

    Tampieri, Francesco; Barbon, Antonio; Tommasini, Matteo (Elsevier BV, 2021-06)
    Article
    Open Access
    Coronene and corannulene are popular structures that have provided the basis for the investigation of extended carbon-based structures, like graphene, fullerene and their derivatives. Here we address the Jahn-Teller (JT) ...

  • Powder metallurgy with space holder for porous titanium implants: A review 

    Rodríguez Contreras, Alejandra María; Punset Fuste, Miquel; Calero Martínez, José Antonio; Gil Mur, Francisco Javier; Rupérez de Gracia, Elisa; Manero Planella, José María (2021-06)
    Article
    Restricted access - publisher's policy
    One of the biggest challenges in the biocompatibility of implantable metals is the prevention of the stress shielding effect, which is related to the coupling of the bone-metal mechanical properties. This stress shielding ...

  • Mithramycin delivery systems to develop effective therapies in sarcomas 

    Estupiñan, Oscar; Rey Vázquez, Verónica; Tornin Cavielles, Juan; Moris, Francisco; González Meana, M. Victoria (Springer Nature, 2021-12)
    Article
    Open Access
    Covenantee:   Instituto de Investigación Sanitaria del Principado de Asturias
    Sarcomas comprise a group of aggressive malignancies with very little treatment options beyond standard chemotherapy. Reposition of approved drugs represents an attractive approach to identify effective therapeutic compounds. ...

  • Mineralization of titanium surfaces: biomimetic implants 

    Gil Mur, Javier; Manero Planella, José María; Rupérez de Gracia, Elisa; Velasco Ortega, Eugenio; Jimenez Guerra, Álvaro; Ortiz Garcia, Ivan; Monsalve Guil, L (Multidisciplinary Digital Publishing Institute (MDPI), 2021-05-27)
    Article
    Open Access
    Covenantee:   Universitat Internacional de Catalunya / Universidad de Sevilla
    The surface modification by the formation of apatitic compounds, such as hydroxyapatite, improves biological fixation implants at an early stage after implantation. The structure, which is identical to mineral content of ...

  • Selectivity of direct plasma treatment and plasma-conditioned media in bone cancer cell lines 

    Hamouda, Inés; Labay, Cédric Pierre; Ginebra Molins, Maria Pau; Canal Barnils, Cristina (Nature, 2021-12)
    Article
    Open Access
    Atmospheric pressure plasma jets have been shown to impact several cancer cell lines, both in vitro and in vivo. These effects are based on the biochemistry of the reactive oxygen and nitrogen species generated by plasmas ...

  • Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility 

    García Mintegui, Claudia; Córdoba Román, Laura Catalina; Buxadera Palomero, Judit; Marquina, Andrea; Jiménez Piqué, Emilio; Ginebra Molins, Maria Pau; Cortina Pallás, José Luís; Pegueroles Neyra, Marta (2021-12)
    Article
    Open Access
    Covenantee:   Institut de Bioenginyeria de Catalunya
    In the recent decades, zinc (Zn) and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to its degradation rate more suitable than magnesium (Mg) and iron (Fe) alloys. ...

  • 3D printing non-cylindrical strands: morphological and structural implications 

    Raymond Llorens, Santiago; Thorel, Emilie; Liversain, Margaux; Riveiro Rodríguez, Antonio; Pou, Juan; Ginebra Molins, Maria Pau (Elsevier, 2021-10-01)
    Article
    Open Access
    Covenantee:   Mimetis Biomaterials / Universidade de Vigo
    Conventional direct ink writing uses circular nozzles and, therefore, results in cylindrical strands. 3D printing with non-circular nozzles adds new degrees of freedom to this versatile technology, and allows obtaining ...

  • Computed tomography and histological evaluation of xenogenic and biomimetic bone grafts in three-wall alveolar defects in minipigs 

    Raymond Llorens, Santiago; Pastorino Carraz, David; Ginebreda, Ignacio; Maazouz, Yassine; Ortiz, Mònica; Manzanares, Maria Cristina; Ginebra Molins, Maria Pau (2021-05-01)
    Article
    Restricted access - publisher's policy
    Covenantee:   Mimetis Biomaterials / Universitat Internacional de Catalunya / Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental
    Objectives This study aimed to compare the performance of a xenograft (XG) and a biomimetic synthetic graft (SG) in three-wall alveolar defects in minipigs by means of 3D computerised tomography and histology. Materials ...

  • Citric acid passivation of titanium dental implants for minimizing bacterial colonization impact 

    Punset Fuste, Miquel; Vilarrasa Sánchez, Javier; Nart Molina, José; Manero Planella, José María; Bosch Canals, Begoña María; Padrós, Roberto; Pérez Antoñanzas, Román; Gil Mur, Javier (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-12)
    Article
    Open Access
    Covenantee:   Universitat Internacional de Catalunya / Barcelona Dental Institute
    Surface topography and physical-chemical properties usually play a key-role in both osseointegration improvement and bacterial colonization reduction over the surface of dental implants. The aim of this study is to compare ...

  • In vitro assessment of PEEK and titanium implant abutments: screw loosening and microleakage evaluations under dynamic mechanical testing 

    Ortiz Hernández, Mónica; Punset Fuste, Miquel (2020-12)
    Article
    Restricted access - publisher's policy
    Covenantee:   Universitat Internacional de Catalunya
    Statement of problem. Polyetheretherketone (PEEK) has been advocated to replace metal components in dentistry. Although PEEK is a high-performance polymer with a white color, adequate biological response, and resistance ...

  • Functionalization strategies and fabrication of solvent-cast PLLA for bioresorbable stents 

    Schieber, Romain; Raymond Llorens, Santiago; Caparrós, Cristina; Bou Serra, Jordi; Herrero Acero, Enrique; Guebitz, Georg; Canal Barnils, Cristina; Pegueroles Neyra, Marta (MDPI, 2021-02-06)
    Article
    Open Access
    Covenantee:   Austrian Centre of Industrial Biotechnology / BOKU Universität für Bodenkultur Wien
    Actual polymer bioresorbable stents (BRS) generate a risk of device thrombosis as a consequence of the incomplete endothelialization after stent implantation. The material-tissue interactions are not fully controlled and ...

View more