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dc.contributor.authorCarreras, Nuria
dc.contributor.authorAlonso Merino, Cristina
dc.contributor.authorMarti Gelabert, Meritxell
dc.contributor.authorLis Arias, Manuel José
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2015-05-28T10:50:03Z
dc.date.available2016-05-02T00:31:37Z
dc.date.created2015-05-25
dc.date.issued2015-05-25
dc.identifier.citationCarreras, N. [et al.]. Mass transport model through the skin by microencapsulation system. "Journal of microencapsulation", 25 Maig 2015, vol. 32, núm. 4, p. 358-363.
dc.identifier.issn0265-2048
dc.identifier.urihttp://hdl.handle.net/2117/28091
dc.description.abstractSkin drug delivery can be subdivided into topical and transdermal administration. Transdermal administration can take advantage of chemical and physical strategies that can improve skin permeability and allow drug penetration. In this study, the development of a skin penetration profile was carried out by an in vitro technique for a microencapsulated system of ibuprofen. Release experiments were performed using percutaneous absorption tests to determine the evolution of the principle present in each of the different skin compartments as a function of time. A general kinetic model for a microencapsulated structure as a mass transport system through the skin was applied. This model could predict the penetration profile of encapsulated substances through skin from biofunctional textiles as well as estimate the dosage profile of the active principle. The apparent diffusion coefficients found were 1.20¿×¿10-7¿cm/s for the stratum corneum and higher for the rest of the skin 6.67¿×¿10-6¿cm/s
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licences/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria tèxtil ::Teixits::Teixits mèdics
dc.subjectÀrees temàtiques de la UPC::Enginyeria química::Indústries químiques::Química tèxtil
dc.subject.lcshMicroencapsulation--Technological innovations
dc.subject.lcshIbuprofen--therapeutic use
dc.subject.lcshDrug delivery systems--Technological innovations
dc.subject.lcshSkin--Permeability
dc.subject.othermathematical model
dc.subject.otherMass transport
dc.subject.otherskin
dc.subject.othermicrocapsules
dc.subject.otherpercutaneous absorption
dc.subject.othermicroencapsulation
dc.subject.otherbiofunctional textile substrates
dc.subject.otherin vitro skin delivery
dc.subject.otheribuprofen
dc.titleMass transport model through the skin by microencapsulation system
dc.typeArticle
dc.subject.lemacMedicaments -- Administració
dc.subject.lemacNanoestructures -- Ús terapèutic
dc.subject.lemacTeixits i tèxtils -- Innovacions tecnològiques
dc.contributor.groupUniversitat Politècnica de Catalunya. POLQUITEX - Materials Polimérics i Química Téxtil
dc.identifier.doi10.3109/02652048.2015.1028495
dc.relation.publisherversionhttp://informahealthcare.com/doi/abs/10.3109/02652048.2015.1028495
dc.rights.accessOpen Access
drac.iddocument15732158
dc.description.versionPostprint (author’s final draft)
upcommons.citation.authorCarreras, N.; Alonso, C.; Marti, M.; Lis, M.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameJournal of microencapsulation


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