Show simple item record

dc.contributor.authorTorres Sánchez, Alejandro
dc.contributor.authorGomez Gardenes, Jesus
dc.contributor.authorFalo, Fernando
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Matemàtica Aplicada III
dc.date.accessioned2015-05-05T08:55:28Z
dc.date.available2015-05-05T08:55:28Z
dc.date.created2015-03-01
dc.date.issued2015-03-01
dc.identifier.citationTorres, A.; Gomez, J.; Falo, F. An integrative approach for modeling and simulation of heterocyst pattern formation in cyanobacteria filaments. "PLOS computational biology", 01 Març 2015, vol. 11, núm. 3, p. 1/18-18/18.
dc.identifier.issn1553-734X
dc.identifier.urihttp://hdl.handle.net/2117/27742
dc.description.abstractHeterocyst differentiation in cyanobacteria filaments is one of the simplest examples of cellular differentiation and pattern formation in multicellular organisms. Despite of the many experimental studies addressing the evolution and sustainment of heterocyst patterns and the knowledge of the genetic circuit underlying the behavior of single cyanobacterium under nitrogen deprivation, there is still a theoretical gap connecting these two macroscopic and microscopic processes. As an attempt to shed light on this issue, here we explore heterocyst differentiation under the paradigm of systems biology. This framework allows us to formulate the essential dynamical ingredients of the genetic circuit of a single cyanobacterium into a set of differential equations describing the time evolution of the concentrations of the relevant molecular products. As a result, we are able to study the behavior of a single cyanobacterium under different external conditions, emulating nitrogen deprivation, and simulate the dynamics of cyanobacteria filaments by coupling their respective genetic circuits via molecular diffusion. These two ingredients allow us to understand the principles by which heterocyst patterns can be generated and sustained. In particular, our results point out that, by including both diffusion and noisy external conditions in the computational model, it is possible to reproduce the main features of the formation and sustainment of heterocyst patterns in cyanobacteria filaments as observed experimentally. Finally, we discuss the validity and possible improvements of the model.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
dc.subject.lcshCyanobacteria filaments
dc.subject.lcshComputational biology
dc.subject.otherSP STRAIN PCC-7120
dc.subject.otherANABAENA SP PCC-7120
dc.subject.otherBLUE-GREEN-ALGA
dc.subject.otherPCC 7120
dc.subject.otherNITROGEN-FIXATION
dc.subject.otherTRANSCRIPTION FACTOR
dc.subject.otherBASIC MECHANISMS
dc.subject.otherDIFFERENTIATION
dc.subject.otherNTCA
dc.subject.otherEXPRESSION
dc.titleAn integrative approach for modeling and simulation of heterocyst pattern formation in cyanobacteria filaments
dc.typeArticle
dc.subject.lemacCianobacteris
dc.subject.lemacBiologia computacional
dc.identifier.doi10.1371/journal.pcbi.1004129
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004129
dc.rights.accessOpen Access
local.identifier.drac15620904
dc.description.versionPostprint (published version)
local.citation.authorTorres, A.; Gomez, J.; Falo, F.
local.citation.publicationNamePLOS computational biology
local.citation.volume11
local.citation.number3
local.citation.startingPage1/18
local.citation.endingPage18/18
dc.identifier.pmid25816286


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

All rights reserved. This work is protected by the corresponding intellectual and industrial property rights. Without prejudice to any existing legal exemptions, reproduction, distribution, public communication or transformation of this work are prohibited without permission of the copyright holder