Show simple item record

dc.contributor.authorGil Mur, Francisco Javier
dc.contributor.authorMas Moruno, Carlos
dc.contributor.authorFraioli, Roberta
dc.contributor.authorAlbericio Palomera, Fernando
dc.contributor.authorManero Planella, José María
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2015-05-04T11:30:15Z
dc.date.created2014-03-27
dc.date.issued2014-03-27
dc.identifier.citationGil, F.J. [et al.]. A novel peptide-based platform for the dual presentation of biologically-active peptide motifs on biomaterials. "ACS applied materials and interfaces", 27 Març 2014, vol. 6, p. 2525-2536.
dc.identifier.issn1944-8244
dc.identifier.urihttp://hdl.handle.net/2117/27719
dc.description.abstractBiofunctionalization of metallic materials with cell adhesive molecules derived from the extracellular matrix is a feasible approach to improve cell–material interactions and enhance the biointegration of implant materials (e.g., osseointegration of bone implants). However, classical biomimetic strategies may prove insufficient to elicit complex and multiple biological signals required in the processes of tissue regeneration. Thus, newer strategies are focusing on installing multifunctionality on biomaterials. In this work, we introduce a novel peptide-based divalent platform with the capacity to simultaneously present distinct bioactive peptide motifs in a chemically controlled fashion. As a proof of concept, the integrin-binding sequences RGD and PHSRN were selected and introduced in the platform. The biofunctionalization of titanium with this platform showed a positive trend towards increased numbers of cell attachment, and statistically higher values of spreading and proliferation of osteoblast-like cells compared to control noncoated samples. Moreover, it displayed statistically comparable or improved cell responses compared to samples coated with the single peptides or with an equimolar mixture of the two motifs. Osteoblast-like cells produced higher levels of alkaline phosphatase on surfaces functionalized with the platform than on control titanium; however, these values were not statistically significant. This study demonstrates that these peptidic structures are versatile tools to convey multiple biofunctionality to biomaterials in a chemically defined manner
dc.format.extent12 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshBiomedical materials
dc.subject.lcshPeptides
dc.subject.otherbiofunctionalization
dc.subject.othercell adhesive peptide
dc.subject.othercell adhesion
dc.subject.otherpeptide platform
dc.subject.othertitanium
dc.subject.otherRGD peptide
dc.subject.otherPHSRN peptide
dc.titleA novel peptide-based platform for the dual presentation of biologically-active peptide motifs on biomaterials
dc.typeArticle
dc.subject.lemacMaterials biomèdics
dc.subject.lemacPèptids
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1021/am5001213
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://pubs.acs.org/doi/abs/10.1021/am5001213
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac15592548
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorGil, F.J.; Mas-Moruno, C.; Fraioli, R.; Albericio, F.; Manero, J.
local.citation.publicationNameACS applied materials and interfaces
local.citation.volume6
local.citation.startingPage2525
local.citation.endingPage2536


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain