Electrospinning of gelatin fibers using solutions with low acetic acid concentration: effect of solvent composition on both diameter of electrospun fibers and cytotoxicity

Document typeArticle
Defense date2015-03-13
PublisherWiley
Rights accessOpen Access
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Attribution 3.0 Spain
Abstract
Gelatin fibers were prepared by electrospinning of gelatin/acetic acid/water ternary mixtures with the aim of studying the feasibility of fabricating gelatin nanofiber mats at room temperature using an alternative benign solvent by significantly reducing the acetic acid concentration. The results showed that gelatin nanofibers can be optimally electrospun with low acetic acid concentration (25% v/v) combined with gelatin concentrations higher than 300 mg/ml. Both gelatin solutions and electrospun gelatin mats (prepared with different acetic acid aqueous solutions) were analyzed by FTIR and DSC techniques in order to determine the chemical and structure changes
of the polymer. The electrospun gelatin mats fabricated from solutions with low acetic acid content showed some advantages as the maintenance of the decomposition temperature of the pure gelatin (~230ºC) and the reduction of the acid content on electrospun mats, which allowed to reach a cell viability upper than 90% (analyzed by
cell viability test using human dermal fibroblast and embryonic kidney cells). This study has also analyzed the influence of gelatin and acetic acid concentration both on the solution viscosity and the electrospun fiber diameter, obtaining a clear relationship between these parameters
CitationErencia, M. [et al.]. Electrospinning of gelatin fibers using solutions with low acetic acid concentration: effect of solvent composition on both diameter of electrospun fibers and cytotoxicity. "Journal of Applied Polymer Science (online)", 13 Març 2015, vol. 132, núm. 25, p. 42115 (1/11)-42115 (11(11).
ISSN1097-4628
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/app.42115/abstract
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