Design considerations for a CMOS Lab-on-Chip microheater array to facilitate the in vitro thermal stimulation of neurons
Tipo de documentoTexto en actas de congreso
Fecha de publicación2014
EditorInstitute of Electrical and Electronics Engineers (IEEE)
Condiciones de accesoAcceso restringido por política de la editorial
This paper identifies and addresses key design considerations and trade-offs in the implementation of a CMOS high-resolution microheater array for Lab-on-Chip (LOC) applications. Specifically, this is investigated in the context of facilitating the in vitro thermal stimulation of single neurons. The paper analyses the electro-thermal response (by means of COMSOL simulations) and reliability issues (such as melting and electromigration) of different microheater designs. The analysis shows that a small-area heater is more efficient in terms of power, but it has more reliability problems essentially due to electromigration effects. For the proposed heater designs, the expected lifetime is a few days (in continuous operation) in the worst scenario, which is still generally acceptable for LOC applications.
CitaciónReverter, F. [et al.]. Design considerations for a CMOS Lab-on-Chip microheater array to facilitate the in vitro thermal stimulation of neurons. A: IEEE International Symposium on Circuits and Systems. "2014 IEEE International Symposium on Circuits and Systems (ISCAS 2014): Melbourne, Australia: 1-5 June 2014". Melbourne: Institute of Electrical and Electronics Engineers (IEEE), 2014, p. 630-633.
Versión del editorhttp://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=6865214&tag=1
|versio_conference.pdf||Article a congres||784.1Kb||Acceso restringido|