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dc.contributor.authorCaparrós Vázquez, Cristina Maria
dc.contributor.authorGuillem Martí, Jordi
dc.contributor.authorMolmeneu Trias, Meritxell
dc.contributor.authorPunset Fuste, Miquel
dc.contributor.authorGil Mur, Francisco Javier
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2015-04-07T10:54:01Z
dc.date.created2014-06-16
dc.date.issued2014-06-16
dc.identifier.citationCaparros, C. [et al.]. Mechanical propertiesand in vitro biological response toporoustitaniumalloysprepared for useinintervertebralimplants. "Journal of the mechanical behavior of biomedical materials", 16 Juny 2014, vol. 39, p. 79-86.
dc.identifier.issn1751-6161
dc.identifier.urihttp://hdl.handle.net/2117/27132
dc.description.abstractThe generation of titanium foams is a promising strategy for modifying the mechanical properties of intervertebral reinforcements. Thus, the aim of this study was to compare the in vitro biological response of Ti6Al4V alloys with different pore sizes for use in intervertebral implants in terms of the adhesion, proliferation, and differentiation of pre-osteoblastic cells. We studied the production of Ti6Al4V foams by powder metallurgy and the biological responses to Ti6Al4V foams were assessed in terms of different pore interconnectivities and elastic moduli. The Ti6Al4V foams obtained had similar porosities of approximately 34%, but different pore sizes (66 µm for fine Ti6Al4V and 147 µm for coarse Ti6Al4V) due to the sizes of the microsphere used. The Ti6Al4V foams had a slightly higher Young¿s modulus compared with cancellous bone. The dynamic mechanical properties of the Ti6Al4V foams were slightly low, but these materials can satisfy the requirements for intervertebral prosthesis applications. The cultured cells colonized both sizes of microspheres near the pore spaces, where they occupied almost the entire area of the microspheres when the final cell culture time was reached. No statistical differences in cell proliferation were observed; however, the cells filled the pores on fine Ti6Al4V foams but they only colonized the superficial microspheres, whereas the cells did not fill the pores on coarse Ti6Al4V foams but they were distributed throughout most of the material. In addition, the microspheres with wide pores (coarse Ti6Al4V) stimulated higher osteoblast differentiation, as demonstrated by the Alcaline Phosphatase (ALP) activity. Our in vitro results suggest that foams with wide pore facilitate internal cell colonization and stimulate osteoblast differentiation
dc.format.extent8 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshTitanium alloys
dc.subject.lcshImplants, Artificial.
dc.subject.otherBiologicalresponse
dc.subject.otherFatigue
dc.subject.otherMetallic foam
dc.subject.otherPorous titanium
dc.titleMechanical propertiesand in vitro biological response toporoustitaniumalloysprepared for useinintervertebralimplants
dc.typeArticle
dc.subject.lemacTitani -- Aliatges
dc.subject.lemacImplants artificials
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.jmbbm.2014.05.029
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jmbbm.2014.05.029
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac15551650
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorCaparros, C.; Guillem-Marti, J.; Molmeneu, M.; Punset, M.; Gil, F.J.
local.citation.publicationNameJournal of the mechanical behavior of biomedical materials
local.citation.volume39
local.citation.startingPage79
local.citation.endingPage86


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain