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Anhydric maleic functionalization and polyethylene glycol grafting of lactide-co-trimethylene carbonate copolymers

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10.1016/j.msec.2014.05.069
 
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Díaz Andrade, Angélica María
Valle Mendoza, Luis Javier delMés informacióMés informacióMés informació
Franco García, María LourdesMés informacióMés informacióMés informació
Sarasua, Jose-Ramon
Estrany Coda, FrancescMés informacióMés informacióMés informació
Puiggalí Bellalta, JordiMés informacióMés informacióMés informació
Document typeArticle
Defense date2014-09-01
Rights accessRestricted access - publisher's policy
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Lactide and trimethylene carbonate copolymers were successfully grafted with polyethylene glycol via previous functionalization with maleic anhydride and using N,N'-diisopropylcarbodiimide as condensing agent. Maleinization led to moderate polymer degradation. Specifically, the weight average molecular weight decreased from 36,200 to 30,200 g/mol for the copolymer having 20 mol% of trimethylene carbonate units. Copolymers were characterized by differential scanning calorimetry, thermogravimetry and X-ray diffraction. Morphology of spherulites and lamellar crystals was evaluated with optical and atomic force microscopies, respectively. The studied copolymers were able to crystallize despite the randomness caused by the trimethylene carbonate units and the lateral groups. Contact angle measurements indicated that PEG grafted copolymers were more hydrophilic than parent copolymers. This feature justified that enzymatic degradation in lipase medium and proliferation of both epithelial-like and fibroblast-like cells were enhanced. Grafted copolymers were appropriate to prepare regular drug loaded microspheres by the oil-in-water emulsion method. Triclosan release from loaded microspheres was evaluated in two media. © 2014 Elsevier B.V.
CitationDiaz, A. [et al.]. Anhydric maleic functionalization and polyethylene glycol grafting of lactide-co-trimethylene carbonate copolymers. "Materials science and engineering C. Biomimetic and supramolecular systems", 01 Setembre 2014, vol. 42, p. 517-528. 
URIhttp://hdl.handle.net/2117/24132
DOI10.1016/j.msec.2014.05.069
ISSN0928-4931
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S092849311400352X
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  • Departament d'Enginyeria Química - Articles de revista [2.117]
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