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Effect of structure, topography and chemistry on fibroblast adhesion and morphology

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hdl:2117/24131

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Mateos Timoneda, Miguel ÁngelMés informació
Castaño Linares, ÓscarMés informació
Planell Estany, Josep AntonMés informacióMés informació
Engel López, ElisabethMés informacióMés informacióMés informació
Document typeArticle
Defense date2014-07
Rights accessRestricted access - publisher's policy
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Surface biofunctionalisation of many biodegradable polymers is one of the used strategies to improve the biological activity of such materials. In this work, the introduction of collagen type I over the surface of a biodegradable polymer (poly lactic acid) processed in the forms of films and fibers leads to an enhancing of the cellular adhesion of human dermal fibroblast when compared to unmodified polymer and biomolecule-physisorbed polymer surface. The change of topography of the material does not affect the cellular adhesion but results in a higher proliferation of the fibroblast cultured over the fibers. Moreover, the difference of topography governs the cellular morphology, i.e. cells adopt a more stretched conformation where cultured over the films while a more elongated with lower area morphology are obtained for the cells grown over the fibers. This study is relevant for designing and modifying different biodegradable polymers for their use as scaffolds for different applications in the field of Tissue Engineering and Regenerative Medicine.
CitationMateos, M. [et al.]. Effect of structure, topography and chemistry on fibroblast adhesion and morphology. "Journal of materials science. Materials in medicine", Juliol 2014, vol. 25, núm. 7, p. 1781-1787. 
URIhttp://hdl.handle.net/2117/24131
DOI10.1007/s10856-014-5199-z
ISSN0957-4530
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  • IBEC - Institute for Bioengineering of Catalonia - Articles de revista [50]
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [961]
  • BBT - Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [364]
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