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dc.contributor.authorMaazouz, Yassine
dc.contributor.authorMontufar Jiménez, Edgar Benjamin
dc.contributor.authorGuillem Martí, Jordi
dc.contributor.authorFleps, I.
dc.contributor.authorOhman, C.
dc.contributor.authorPersson, C.
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2014-09-19T10:48:33Z
dc.date.available2014-09-19T10:48:33Z
dc.date.created2014-01-01
dc.date.issued2014-01-01
dc.identifier.citationMaazouz, Y. [et al.]. Robocasting of biomimetic hydroxyapatite scaffolds using self-setting inks. "Journal of materials chemistry B", 01 Gener 2014, vol. 2, núm. 33, p. 5378-5386.
dc.identifier.issn2050-750X
dc.identifier.urihttp://hdl.handle.net/2117/24117
dc.description.abstractLow temperature self-setting ceramic inks have been scarcely investigated for solid freeform fabrication processes. This work deals with the robocasting of alpha-tricalcium phosphate/gelatine reactive slurries as a bioinspired self-setting ink for the production of biomimetic hydroxyapatite/gelatine scaffolds. A controlled and totally interconnected pore network of similar to 300 mu m was obtained after ink printing and setting, with the struts consisting of a micro/nanoporous matrix of needle-shaped calcium deficient hydroxyapatite crystals, with a high specific surface area. Gelatine was effectively retained by chemical crosslinking. The setting reaction of the ink resulted in a significant increase of both the elastic modulus and the compressive strength of the scaffolds, which were within the range of the human trabecular bone. In addition to delaying the onset of the setting reaction, thus providing enough time for printing, gelatine provided the viscoelastic properties to the strands to support their own weight, and additionally enhanced mesenchymal stem cell adhesion and proliferation on the surface of the scaffold. Altogether this new processing approach opens good perspectives for the design of hydroxyapatite scaffolds for bone tissue engineering with enhanced reactivity and resorption rate.
dc.format.extent9 p.
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshTissue engineering
dc.subject.otherCALCIUM-PHOSPHATE CEMENT
dc.subject.otherMECHANICAL-PROPERTIES
dc.subject.otherBONE REGENERATION
dc.subject.otherGELATIN
dc.subject.otherPROLIFERATION
dc.subject.otherTOPOGRAPHY
dc.subject.otherOSTEOBLAST
dc.subject.otherINTEGRINS
dc.subject.otherCOLLAGEN
dc.subject.otherFOAMS
dc.titleRobocasting of biomimetic hydroxyapatite scaffolds using self-setting inks
dc.typeArticle
dc.subject.lemacEnginyeria de teixits
dc.contributor.groupUniversitat Politècnica de Catalunya. BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1039/c4tb00438h
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB00438H#!divAbstract
dc.rights.accessOpen Access
drac.iddocument15115309
dc.description.versionPostprint (published version)
upcommons.citation.authorMaazouz, Y.; Montufar, E.; Guillem, J.; Fleps, I.; Ohman, C.; Persson, C.; Ginebra, M.P.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameJournal of materials chemistry B
upcommons.citation.volume2
upcommons.citation.number33
upcommons.citation.startingPage5378
upcommons.citation.endingPage5386


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