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dc.contributor.authorLanz Landazuri, Alberto
dc.contributor.authorMartínez de Ilarduya Sáez de Asteasu, Domingo Antxon
dc.contributor.authorPortilla Arias, Jose Antonio
dc.contributor.authorGarcía Álvarez, Montserrat
dc.contributor.authorHoller, Eggehard
dc.contributor.authorLjubimova, Julia
dc.contributor.authorMuñoz Guerra, Sebastián
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2014-09-17T08:24:02Z
dc.date.created2014-09-01
dc.date.issued2014-09-01
dc.identifier.citationLanz, A. [et al.]. Nanoparticles of esterified polymalic acid for controlled anticancer drug release. "Macromolecular bioscience", 01 Setembre 2014, vol. 14, núm. 9, p. 1325-1336.
dc.identifier.issn1616-5187
dc.identifier.urihttp://hdl.handle.net/2117/24073
dc.description.abstractEsterification of microbial poly(malic acid) is performed with either ethanol or 1-butanol to obtain polymalate conjugates capable to form nanoparticles (100–350 nm). Degradation under physiological conditions takes place with release of malic acid and the corresponding alcohol as unique degradation products. The anticancer drugs Temozolomide and Doxorubicin are encapsulated in nanoparticles with efficiency of 17 and 37%, respectively. In vitro drug release assays show that Temozolomide is almost completely discharged in a few hours whereas Doxorubicin is steadily released along several days. Drug-loaded nano-particles show remarkable effectiveness against cancer cells. Partially ethylated poly(malic acid) nano-particles are those showing the highest cellular uptake.
dc.format.extent12 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshNanoparticles--Therapeutic use
dc.subject.lcshAntineoplastic agents
dc.subject.otherbiodegradable drug delivery systems
dc.subject.otherpoly(malic acid)
dc.subject.otherpoly(malic acid) nanoparticles
dc.titleNanoparticles of esterified polymalic acid for controlled anticancer drug release
dc.typeArticle
dc.subject.lemacNanopartícules -- Ús terapèutic
dc.subject.lemacMedicaments antineoplàstics
dc.contributor.groupUniversitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics
dc.identifier.doi10.1002/mabi.201400124
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/mabi.201400124/abstract
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac15143365
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorLanz, A.; Martinez de Ilarduya, A.; Portilla-Arias, J.; Garcia, M.; Holler, E.; Ljubimova, J.; Muñoz, S.
local.citation.publicationNameMacromolecular bioscience
local.citation.volume14
local.citation.number9
local.citation.startingPage1325
local.citation.endingPage1336


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