Recent Submissions

  • Human CASPR2 antibodies reversibly alter memory and the CASPR2 protein complex 

    Joubert, Bastien; Petit-Pedrol, Mar; Planagumà, Jesús; Mannara, Francesco; Radosevic, Marija; Marsal, Maria; Maudes, Estibaliz; García-Serra, Anna; Aguilar, Esther; Andrés-Bilbé, Alba; Gasull, Xavier; Loza-Alvarez, Pablo; Sabater, Lidia; Rosenfeld, Myrna R.; Dalmau, Josep (Wiley, 2022-03-07)
    Article
    Open Access
    Objective The encephalitis associated with antibodies against contactin-associated protein-like 2 (CASPR2) is presumably antibody-mediated but the antibody effects and whether they cause behavioral alterations are not ...
  • The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior 

    Venturini, Valeria; Pezzano, Fabio; Català Castro, Frederic; Häkkinen, Hanna-Maria; Jiménez-Delgado, Senda; Colomer Rosell, Mariona; Marro, Monica; Tolosa-Ramon, Queralt; Paz-López, Sonia; Valverde, Miguel A.; Weghuber, Julian; Loza- Alvarez, Pablo; Krieg, Michael; Wieser, Stefan; Ruprecht, Verena (ACS, 2020-10-16)
    Article
    Open Access
    Single cells continuously experience and react to mechanical challenges in three-dimensional tissues. Spatial constraints in dense tissues, physical activity, and injury all impose changes in cell shape. How cells can ...
  • Unravelling the Metabolic Progression of Breast Cancer Cells to Bone Metastasis by Coupling Raman Spectroscopy and a Novel Use of Mcr-Als Algorithm 

    Marro, Monica; Nieva, Claudia; Juan, Anna de; Sierra, Angels (ACS, 2018-03-28)
    Open Access
    Raman spectroscopy (RS) has shown promise as a tool to reveal biochemical changes that occur in cancer processes at the cellular level. However, when analyzing clinical samples, RS requires improvements to be able to resolve ...
  • Light-sheet microscopy: a tutorial 

    Olarte, Omar E.; Andilla, Jordi; Gualda, Emilio J.; Loza-Alvarez, Pablo (OSA, 2018-01-19)
    Article
    Open Access
    This paper is intended to give a comprehensive review of light-sheet (LS) microscopy from an optics perspective. As such, emphasis is placed on the advantages that LS microscope configurations present, given the degree of ...
  • Interference with Clp protease impairs carotenoid accumulation during tomato fruit ripening 

    Andrea, Lucio D’; Simon-Moya, Miguel; Llorente, Briardo; Llamas, Ernesto; Loza-Alvarez, Pablo; Li, Li; Rodriguez-Concepcion, Manuel (Society for Experimental Biology, 2018-01-29)
    Article
    Open Access
    Profound metabolic and structural changes are required for fleshy green fruits to ripen and become colorful and tasty. In tomato (Solanum lycopersicum), fruit ripening involves the differentiation of chromoplasts, specialized ...
  • Transcriptome analysis in tissue sectors with contrasting crocins accumulation provides novel insights into apocarotenoid biosynthesis and regulation during chromoplast biogenesis 

    Ahrazem, O.; Argandoña, J.; Fiore, A.; Aguado, C.; Luján, R.; Rubio-Moraga, A.; Marro, M.; Araujo-Andrade, C.; Loza-Alvarez, P.; Diretto, G.; Gómez-Gómez, L. (Nature, 2018-02-12)
    Article
    Open Access
    Crocins, the red soluble apocarotenoids of saffron, accumulate in the flowers of Crocus species in a developmental and tissue-specific manner. In Crocus sieberi, crocins accumulate in stigmas but also in a distinct yellow ...
  • Synaptic phosphorylated a-synuclein in dementia with Lewy bodies 

    Colom-Cadena, Martí; Pegueroles, Jordi; Herrmann, Abigail G.; Henstridge, Christopher M.; Muñoz, Laia; Querol-Vilaseca, Marta; San Martin, Carla; Luque-Cabecerans, Joan; Clarimon, Jordi; Belbin, Olivia; Nuñez-Llaves, Raúl; Blesa, Rafael; Smith, Colin; McKenzie, Chris-Anne; Frosch, Matthew P.; Roe, Allyson; Fortea, Juan; Andilla, Jordi; Loza-Alvarez, Pablo; Gelpi, Ellen; Hyman, Bradley T.; Spires-Jone, Tara L.; Lleó, Alberto (Oxford, 2017-11-23)
    Article
    Open Access
    Dementia with Lewy bodies is characterized by the accumulation of Lewy bodies and Lewy neurites in the CNS, both of which are composed mainly of aggregated a-synuclein phosphorylated at Ser129. Although phosphorylated ...
  • High-Resolution Morphological Approach to Analyse Elastic Laminae Injuries of the Ascending Aorta in a Murine Model of Marfan Syndrome 

    López-Guimet, Júlia; Andilla, Jordi; Loza-Álvarez, Pablo; Egea, Gustavo (Nature, 2017-05-04)
    Article
    Open Access
    In Marfan syndrome, the tunica media is disrupted, which leads to the formation of ascending aortic aneurysms. Marfan aortic samples are histologically characterized by the fragmentation of elastic laminae. However, ...
  • STED imaging performance estimation by means of Fourier transform analysis 

    Merino, David; Mallabiabarrena, Arrate; Andilla, Jordi; Artigas García, David; Zimmermann, Timo; Loza Álvarez, Pablo (OSA, 2017-04-17)
    Article
    Open Access
    Due to relatively high powers used in STED, biological samples may be affected by the illumination in the process of image acquisition. Similarly, the performance of the system may be limited by the sample itself. ...
  • Polarized cortical tension drives zebrafish epiboly movements 

    Hernández-Vega, Amayra; Marsal, María; Pouille, Philippe-Alexandre; Tosi, Sebastien; Colombelli, Julien; Luque, Tomás; Navajas, Daniel; Pagonabarraga, Ignacio; Martín-Blanco, Enrique (EMBOpress, 2016-11-09)
    Article
    Open Access
    The principles underlying the biomechanics of morphogenesis are largely unknown. Epiboly is an essential embryonic event in which three tissues coordinate to direct the expansion of the blastoderm. How and where forces ...
  • Two photon versus one photon fluorescence excitation in whispering gallery mode microresonators 

    Pastells, Carme; Marco, M. Pilar; Merino, David; Loza-Álvarez, Pablo; Pasquardini, Laura; Lorenzo, Lunelli; Pederzolli, Cecilia; Daldosso, Nicola; Farnesi, Daniele; Berneschi, Simone; Righini, Giancarlo C.; Quercioli, Franco; Conti, Gualtiero Nunzi; Soria, Silvia (ScienceDirect, 2016-02-01)
    Article
    Open Access
    We investigate the feasibility of both one photon and two photon fluorescence excitation using whispering gallery mode microresonators. We report the linear and non linear fluorescence real-time detection of labeled IgG ...
  • Conformational changes in matrix-isolated 6-methoxyindole: Effects of the thermal and infrared light excitations 

    Lopes Jesus, A. J.; Reva, I.; Araujo-Andrade, Cuauhtemoc; Fausto, R. (AIP, 2016-03-25)
    Article
    Open Access
    Conformational changes induced thermally or upon infrared excitation of matrix-isolated 6-methoxyindole were investigated. Narrowband near-infrared excitation of the first overtone of the N–H stretching vibration of each ...

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