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The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow
(2024-02-01)
Article
Restricted access - publisher's policyThe language of biology at the scale of the cell is constituted of alphabets represented by biomolecules. These are stitched together in a variety of ways to create meaning. We argue that the phrases of this language are ... -
The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites
(Rockefeller University Press, 2020-11-06)
Article
Open AccessIn response to cholesterol deprivation, SCAP escorts SREBP transcription factors from the endoplasmic reticulum to the Golgi complex for their proteolytic activation, leading to gene expression for cholesterol synthesis ... -
Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T cell migration
(Biophysical Society, 2021-06-01)
Article
Open AccessThe leukocyte specific β2-integrin LFA-1, and its ligand ICAM-1 expressed on endothelial cells (ECs), are involved in the arrest, adhesion and transendothelial migration of leukocytes. Although the role of mechanical ... -
PLANT: A Method for Detecting Changes of Slope in Noisy Trajectories
(ScienceDirect, 2018-05-08)
Article
Open AccessTime traces obtained from a variety of biophysical experiments contain valuable information on underlying processes occurring at the molecular level. Accurate quantification of these data can help explain the details of ... -
Optical Antenna-Based Fluorescence Correlation Spectroscopy to Probe the Nanoscale Dynamics of Biological Membranes
(ACS, 2017-12-14)
Article
Open AccessThe plasma membrane of living cells is compartmentalized at multiple spatial scales ranging from the nano- to the mesoscale. This nonrandom organization is crucial for a large number of cellular functions. At the nanoscale, ... -
TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes
(eLife Sciences Publications, 2018-03-07)
Article
Open AccessCollagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky ... -
Planar Optical Nanoantennas Resolve Cholesterol-Dependent Nanoscale Heterogeneities in the Plasma Membrane of Living Cells
(ACS, 2017-09-19)
Article
Open AccessOptical nanoantennas can efficiently confine light into nanoscopic hotspots, enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers ... -
Transient Nanoscopic Phase Separation in Biological Lipid Membranes Resolved by Planar Plasmonic Antennas
(ACS, 2017-07-11)
Article
Open AccessNanoscale membrane assemblies of sphingolipids, cholesterol, and certain proteins, also known as lipid rafts, play a crucial role in facilitating a broad range of important cell functions. Whereas on living cell membranes ... -
Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network
(Embo press, 2017-04-10)
Article
Open AccessSphingolipids are membrane lipids, which are globally required for eukaryotic life. Sphingolipid composition varies among endomembranes with pre- and post-Golgi compartments being poor and rich in sphingolipids, respectively. ... -
Sphingomyelin metabolism controls the shape and function of the Golgi cisternae
(eLife Sciences Publications, 2017-05-13)
Article
Open AccessThe flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us ... -
In-plane plasmonic antenna arrays with surface nanogaps for giant fluorescence enhancement
(ACS, 2017-02-10)
Article
Open AccessOptical nanoantennas have a great potential for enhancing light-matter interactions at the nanometer scale, yet fabrication accuracy and lack of scalability currently limit ultimate antenna performance and applications. ... -
Roadmap on biosensing and photonics with advanced nano-optical methods
(IOP, 2016-05-10)
Article
Open AccessThis roadmap, through the contributions of ten groups worldwide, contains different techniques, methods and materials devoted to sensing in nanomedicine. Optics is used in different ways in the detection schemes. Raman, ...
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