Medical optics
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Recent Submissions
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Liquid phantoms for near-infrared and diffuse correlation spectroscopies with tunable optical and dynamic properties
(OSA, 2018-04-04)
Article
Open AccessWe present the recipe and characterization for preparing liquid phantoms that are suitable for both near-infrared spectroscopy and diffuse correlation spectroscopy. The phantoms have well-defined and tunable optical and ... -
Cerebral vasoreactivity in response to a headof-bed position change is altered in patients with moderate and severe obstructive sleep apnea
(PLOS, 2018-03-18)
Article
Open AccessObstructive sleep apnea (OSA) can impair cerebral vasoreactivity and is associated with an increased risk of cerebrovascular disease. Unfortunately, an easy-to-use, non-invasive, portable monitor of cerebral vasoreactivity ... -
Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
(OSA, 2018-02-21)
Article
Open AccessIn this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous ... -
Concurrent measurement of cerebral hemodynamics and electroencephalography during transcranial direct current stimulation
(SPIE, 2018-01-25)
Article
Open AccessTranscranial direct current stimulation (tDCS) is currently being used for research and treatment of some neurological and neuropsychiatric disorders, as well as for improvement of cognitive functions. In order to better ... -
Time-resolved near infrared light propagation using frequency domain superposition
(OSA, 2017-12-04)
Article
Open AccessTime-resolved temporal point spread function (TPSF) measurement of near infrared spectroscopic (NIRS) data allows the estimation of absorption and reduced scattering properties of biological tissues. Such analysis requires ... -
Compact, multi-exposure speckle contrast optical spectroscopy (SCOS) device for measuring deep tissue blood flow
(OSA, 2017-12-20)
Article
Open AccessSpeckle contrast optical spectroscopy (SCOS) measures absolute blood flow in deep tissue, by taking advantage of multi-distance (previously reported in the literature) or multi-exposure (reported here) approach. This method ... -
Depth sensitivity of frequency domain optical measurements in diffusive media
(OSA, 2017-06-01)
Article
Open AccessThe depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical ... -
Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics
(OSA, 2017-04-19)
Article
Open AccessThe longitudinal effect of an anti-vascular endothelial growth factor receptor 2 (VEGFR-2) antibody (DC 101) therapy on a xenografted renal cell carcinoma (RCC) mouse model was monitored using hybrid diffuse optics. Two ... -
High-density speckle contrast optical tomography (SCOT) for three dimensional tomographic imaging of the small animal brain
(ScienceDirect, 2017-04-05)
Article
Open AccessHigh-density speckle contrast optical tomography (SCOT) utilizing tens of thousands of source-detector pairs, was developed for in vivo imaging of blood flow in small animals. The reduction in cerebral blood flow (CBF) due ... -
Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy
(OSA, 2016-09-01)
Article
Open AccessThe non-invasive, in vivo measurement of microvascular blood flow has the potential to enhance breast cancer therapy monitoring. Here, longitudinal blood flow of 4T1 murine breast cancer (N=125) under chemotherapy was ... -
Noninvasive characterization of the healthy human manubrium using di use optical spectroscopies
(IOP, 2014-06-05)
Article
Open AccessThe abnormal, uncontrolled production of blood cells in the bone marrow causes hematological malignancies which are common and tend to have a poor prognosis. These types of cancers may alter the hemodynamics of bone marrow. ... -
Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts
(SPIE, 2015-07-01)
Article
Open AccessWe introduce and validate a pressure measurement paradigm that reduces extracerebral contamination from superficial tissues in optical monitoring of cerebral blood flow with diffuse correlation spectroscopy (DCS). The ...
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