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dc.contributor.authorMaione, Silvana
dc.contributor.authorFabregat Jové, Georgina
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.authorBallano Ballano, María Gema
dc.contributor.authorCativiela, Carlos
dc.contributor.authorAlemán Llansó, Carlos
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2014-07-24T07:37:54Z
dc.date.created2014-07-01
dc.date.issued2014-07-01
dc.identifier.citationMaione, S. [et al.]. Electro-biocompatibility of conjugates designed by chemical similarity. "Journal of peptide science", 01 Juliol 2014, vol. 20, núm. 7, p. 537-546.
dc.identifier.issn1075-2617
dc.identifier.urihttp://hdl.handle.net/2117/23594
dc.description.abstractThe roughness and thickness of films formed by hybrid conjugates prepared by coupling poly(3,4-ethylenedioxythiophene) and synthetic amino acids bearing a 3,4-ethylenedioxythiophene group in the side chain have been significantly increased using a new synthetic approach. This procedure also provoked a more effective incorporation of the amino acid at the end of the polymer chains, as has been reflected by the electronic and electrochemical properties. Although the surface polarity of all these materials is similar to that of formamide, the hydrophilicity of the conjugates is higher than that of the conducting polymer. The surface energy of all the investigated systems is dominated by the dispersive component, even though the role played by the polar contribution is more important for the conjugates than for the conducting polymer. On the other hand, all the prepared materials behave as bioactive matrices. The electrochemical response of the conjugates coated with cells reflects the electro-compatibility of these two-component substrates. Thus, the ability to exchange charge reversibly of all conjugates increases considerably when they are coated with cellular monolayers, which has attributed to favorable interactions at the interface formed by the conjugate surface and the cellular monolayer. Copyright (c) 2014 European Peptide Society and John Wiley & Sons, Ltd.
dc.format.extent10 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshBiomedical materials
dc.subject.lcshPeptides
dc.subject.lcshPolymers
dc.subject.otherbiocompatibility
dc.subject.otherpeptide-polymer conjugate
dc.subject.otherhydrophilicity
dc.subject.otherpolythiophene
dc.subject.otherCONDUCTING POLYMERS
dc.subject.otherCELL ATTACHMENT
dc.subject.otherNEURAL PROBES
dc.subject.otherPOLYPYRROLE
dc.subject.otherPEPTIDE
dc.subject.otherINTERFACES
dc.subject.otherGROWTH
dc.subject.otherFILMS
dc.subject.otherPOLY(3
dc.subject.other4-ETHYLENEDIOXYTHIOPHENE)
dc.subject.otherADSORPTION
dc.titleElectro-biocompatibility of conjugates designed by chemical similarity
dc.typeArticle
dc.subject.lemacBiocompatibilitat
dc.subject.lemacPèptids
dc.subject.lemacPolímers
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM - Innovació, Modelització i Enginyeria en (BIO) Materials
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.identifier.doi10.1002/psc.2660
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/psc.2660/abstract;jsessionid=8E0386212FBBFCD8F4C21E98ED25845B.f02t04
dc.rights.accessRestricted access - publisher's policy
drac.iddocument15014075
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
upcommons.citation.authorMaione, S.; Fabregat, G.; del Valle, LJ.; Ballano, G.; Cativiela, C.; Aleman, C.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameJournal of peptide science
upcommons.citation.volume20
upcommons.citation.number7
upcommons.citation.startingPage537
upcommons.citation.endingPage546


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