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dc.contributor.authorSanzana, Edgardo
dc.contributor.authorNavarro Toro, Melba Eugenia
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.authorPlanell Estany, Josep Anton
dc.contributor.authorOjeda, Alvaro
dc.contributor.authorMontecinos, Hernan
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2014-07-01T10:30:55Z
dc.date.created2014-06-01
dc.date.issued2014-06-01
dc.identifier.citationSanzana, E. [et al.]. Role of porosity and pore architecture in the in vivo bone regeneration capacity of biodegradable glass scaffolds. "Journal of biomedical materials research. Part A", 01 Juny 2014, vol. 102, núm. 6, p. 1767-1773.
dc.identifier.issn1549-3296
dc.identifier.urihttp://hdl.handle.net/2117/23359
dc.description.abstractThe aim of this work is to shed light on the role of porosity and pore architecture in the in vivo bone regeneration capacity of biodegradable glass scaffolds. A calcium phosphate glass in the system P2O5-CaO-Na2O-TiO2 was foamed using two different porogens, namely albumen and hydrogen peroxide (H2O2); the resulting three-dimensional porous structures were characterized and implanted in New Zealand rabbits to study their in vivo behavior. Scaffolds foamed with albumen displayed a monomodal pore size distribution centered around 150 m and a porosity of 82%, whereas scaffolds foamed with H2O2 showed lower porosity (37%), with larger elongated pores, and multimodal size distribution. After 12 weeks of implantation, histology results revealed a good osteointegration for both types of scaffolds. The quantitative morphometric analysis showed the substitution of the biomaterial by new bone in the case of glasses foamed with albumen. In contrast, bone neoformation and material resorption were significantly lower in the defects filled with the scaffolds foamed with H2O2. The results obtained in this study showed that both calcium phosphate glass scaffolds were osteoconductive, biocompatible, and biodegradable materials. However, differences in porosity, pore architecture, and microstructure led to substantially different in vivo response. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1767-1773, 2014.
dc.format.extent7 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshBone regeneration
dc.subject.lcshBiomedical materials
dc.subject.lcshTissue Scaffolds
dc.subject.otherscaffolds
dc.subject.othercalcium phosphate glasses
dc.subject.othertissue engineering
dc.subject.otherbone substitutes
dc.subject.otherin vivo
dc.subject.otherCALCIUM-PHOSPHATE GLASSES
dc.subject.otherSOL-GEL GLASS
dc.subject.otherCONTROLLED SOLUBILITY
dc.subject.otherBEHAVIOR
dc.subject.otherHYDROXYAPATITE
dc.subject.otherDEGRADATION
dc.subject.otherCERAMICS
dc.subject.otherDEFECTS
dc.titleRole of porosity and pore architecture in the in vivo bone regeneration capacity of biodegradable glass scaffolds
dc.typeArticle
dc.subject.lemacOssos -- Regeneració
dc.subject.lemacBiomaterials
dc.subject.lemacEnginyeria de teixits
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1002/jbm.a.34845
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/jbm.a.34845/pdf
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac14957056
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorSanzana, E.; Navarro, M.; Ginebra, M.P.; Planell, J.; Ojeda, A.; Montecinos, H.
local.citation.publicationNameJournal of biomedical materials research. Part A
local.citation.volume102
local.citation.number6
local.citation.startingPage1767
local.citation.endingPage1773


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