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dc.contributor.authorCastaño Linares, Óscar
dc.contributor.authorSachot, Nadège
dc.contributor.authorXuriguera Martin, Elena
dc.contributor.authorEngel López, Elisabeth
dc.contributor.authorPlanell Estany, Josep Anton
dc.contributor.authorPark, Jaegyun
dc.contributor.authorJin, Guang-Zhen
dc.contributor.authorKim, Tae-Hyun
dc.contributor.authorKim, Joong-Hyun
dc.contributor.authorKim, Hae-Won
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.contributor.otherInstitut de Bioenginyeria de Catalunya
dc.date.accessioned2014-07-01T09:32:14Z
dc.date.created2014-05-28
dc.date.issued2014-05-28
dc.identifier.citationCastaño, O. [et al.]. Angiogenesis in bone regeneration: tailored calcium release in hybrid fibrous scaffolds. "ACS applied materials and interfaces", 28 Maig 2014, vol. 6, núm. 10, p. 7512-7522.
dc.identifier.issn1944-8244
dc.identifier.urihttp://hdl.handle.net/2117/23350
dc.description.abstractIn bone regeneration, silicon-based calcium phosphate glasses (Bioglasses) have been widely used since the 1970s. However, they dissolve very slowly because of their high amount of Si (SiO2 > 45%). Recently, our group has found that calcium ions released by the degradation of glasses in which the job of silicon is done by just 5% of TiO2 are effective angiogenic promoters, because of their stimulation of a cell-membrane calcium sensing receptor (CaSR). Based on this, other focused tests on angiogenesis have found that Bioglasses also have the potential to be angiogenic promoters even with high contents of silicon (80%); however, their slow degradation is still a problem, as the levels of silicon cannot be decreased any lower than 45%. In this work, we propose a new generation of hybrid organically modified glasses, ormoglasses, that enable the levels of silicon to be reduced, therefore speeding up the degradation process. Using electrospinning as a faithful way to mimic the extracellular matrix (ECM), we successfully produced hybrid fibrous mats with three different contents of Si (40, 52, and 70%), and thus three different calcium ion release rates, using an ormoglass-polycaprolactone blend approach. These mats offered a good platform to evaluate different calcium release rates as osteogenic promoters in an in vivo subcutaneous environment. Complementary data were collected to complement Ca2+ release analysis, such as stiffness evaluation by AFM, zeta-potential, morphology evaluation by FESEM, proliferation and differentiation analysis, as well as in vivo subcutaneous implantations. Material and biological characterization suggested that compositions of organic/inorganic hybrid materials with a Si content equivalent to 40%, which were also those that released more calcium, were osteogenic. They also showed a greater ability to form blood vessels. These results suggest that Si-based ormoglasses can be considered an efficient tool for calcium release modulation, which could play a key role in the angiogenic promoting process.
dc.format.extent11 p.
dc.language.isocat
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshBone regeneration
dc.subject.otherangiogenesis
dc.subject.othersol-gel
dc.subject.otherhybrid materials
dc.subject.otherormoglasses
dc.subject.otherelectrospinning
dc.subject.otherMESENCHYMAL STROMAL CELLS
dc.subject.otherEXTRACELLULAR CALCIUM
dc.subject.otherSENSING RECEPTOR
dc.subject.otherBIOACTIVE GLASS
dc.subject.otherMECHANICAL-PROPERTIES
dc.subject.otherCOMPOSITE SCAFFOLDS
dc.subject.otherMC3T3-E1 CELLS
dc.subject.otherSTEM-CELLS
dc.subject.otherIN-VITRO
dc.subject.otherTISSUE
dc.titleAngiogenesis in bone regeneration: tailored calcium release in hybrid fibrous scaffolds
dc.typeArticle
dc.subject.lemacOssos -- Regeneració
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1021/am500885v
dc.relation.publisherversionhttp://pubs.acs.org/doi/abs/10.1021/am500885v
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac14968231
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
dc.contributor.covenanteeTan'guk Taehakkyo
local.citation.authorCastaño, O.; Sachot, N.; Xuriguera, E.; Engel, E.; Planell, J.; Park, J.; Jin, G.; Kim, T.H; Kim, J.; Kim, H-W.
local.citation.publicationNameACS applied materials and interfaces
local.citation.volume6
local.citation.number10
local.citation.startingPage7512
local.citation.endingPage7522


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain