Mostra el registre d'ítem simple

dc.contributor.authorAllouchi, Hassan
dc.contributor.authorNicolai, Beatrice
dc.contributor.authorBarrio Casado, María del
dc.contributor.authorCéolin, René
dc.contributor.authorMahé, Nathalie
dc.contributor.authorTamarit Mur, José Luis
dc.contributor.authorDo, Bernard
dc.contributor.authorRietveld, Ivo B.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
dc.date.accessioned2014-06-26T08:42:34Z
dc.date.available2014-06-26T08:42:34Z
dc.date.created2014-03-01
dc.date.issued2014-03-01
dc.identifier.citationAllouchi, H. [et al.]. On the polymorphism of l -citrulline: Crystal structure and characterization of the orthorhombic d form. "Crystal growth and design", 01 Març 2014, vol. 14, núm. 3, p. 1279-1286.
dc.identifier.issn1528-7483
dc.identifier.urihttp://hdl.handle.net/2117/23302
dc.description.abstractSolid-state properties of active pharmaceutical compounds are closely related to their dissolution behavior and bioavailability, and understanding their phase behavior leads to better control in the drug formulation process. L-Citrulline is an amino acid, which is known to exhibit polymorphism; however, only the structure of the alpha form is reported in the literature. The structure of the form has been elusive due to lack of good quality single crystals. It has been found to be orthorhombic P2(1)2(1)2(1) with the cell parameters a, b, and c respectively 14.895(5) angstrom, 9.852(2) angstrom, and 5.353(2) angstrom. The unit cell contains four molecules, and its volume is 785.5(4) angstrom(3). Both the alpha form and the delta form possess uniaxial negative thermal expansion along the direction of the charge exchange of the L-citrulline zwitterions. In mixtures containing solid and saturated aqueous, solution, the alpha form quickly transforms in a dihydrate, whereas the delta phase persists for over three weeks. Although the evidence is not conclusive, the delta phase is most likely the more stable form and most suitable for storage.
dc.format.extent8 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Farmacologia
dc.subjectÀrees temàtiques de la UPC::Enginyeria química::Química física
dc.subject.lcshPharmaceutical biotechnology industry
dc.subject.lcshChemistry, Physical and theoretical
dc.subject.otherAcid
dc.subject.otherHydrochloride
dc.titleOn the polymorphism of l -citrulline: Crystal structure and characterization of the orthorhombic d form
dc.typeArticle
dc.subject.lemacFarmacologia
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.identifier.doi10.1021/cg401801u
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac14143343
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorAllouchi, H.; Nicolai, B.; Del Barrio, M.; Céolin, R.; Mahé, N.; Tamarit, J. Ll.; Do, B.; Rietveld, I.R.
local.citation.publicationNameCrystal growth and design
local.citation.volume14
local.citation.number3
local.citation.startingPage1279
local.citation.endingPage1286


Fitxers d'aquest items

Imatge en miniatura

Aquest ítem apareix a les col·leccions següents

Mostra el registre d'ítem simple