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dc.contributor.authorDessi, Mariagemiliana
dc.contributor.authorAlvarez Perez, Marco Antonio
dc.contributor.authorDe Santis, Roberto
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.authorPlanell Estany, Josep Anton
dc.contributor.authorAmbrosio, Luigi
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2014-05-13T10:47:21Z
dc.date.created2014-02
dc.date.issued2014-02
dc.identifier.citationDessi, M. [et al.]. Bioactivation of calcium deficient hydroxyapatite with foamed gelatin gel. A new injectable self-setting bone analogue. "Journal of materials science. Materials in medicine", Febrer 2014, vol. 25, núm. 2, p. 283-295.
dc.identifier.issn0957-4530
dc.identifier.urihttp://hdl.handle.net/2117/22962
dc.description.abstractAn alternative approach to bone repair for less invasive surgical techniques, involves the development of biomaterials directly injectable into the injury sites and able to replicate a spatially organized platform with features of bone tissue. Here, the preparation and characterization of an innovative injectable bone analogue made of calcium deficient hydroxyapatite and foamed gelatin is presented. The biopolymer features and the cement self-setting reaction were investigated by rheological analysis. The porous architecture, the evolution of surface morphology and the grains dimension were analyzed with electron microscopy (SEM/ESEM/TEM). The physico-chemical properties were characterized by X-ray diffraction and FTIR analysis. Moreover, an injection test was carried out to prove the positive effect of gelatin on the flow ensuing that cement is fully injectable. The cement mechanical properties are adequate to function as temporary substrate for bone tissue regeneration. Furthermore, MG63 cells and bone marrow-derived human mesenchymal stem cells (hMSCs) were able to migrate and proliferate inside the pores, and hMSCs differentiated to the osteoblastic phenotype. The results are paving the way for an injectable bone substitute with properties that mimic natural bone tissue allowing the successful use as bone filler for craniofacial and orthopedic reconstructions in regenerative medicine.
dc.format.extent13 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshBiomedical materials
dc.titleBioactivation of calcium deficient hydroxyapatite with foamed gelatin gel. A new injectable self-setting bone analogue
dc.typeArticle
dc.subject.lemacBiomaterials
dc.subject.lemacTeixit ossi
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1007/s10856-013-5071-6
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac13848564
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorDessi, M.; Alvarez, M.; De Santis, R.; Ginebra, M.P.; Planell, J.; Ambrosio, L.
local.citation.publicationNameJournal of materials science. Materials in medicine
local.citation.volume25
local.citation.number2
local.citation.startingPage283
local.citation.endingPage295


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain