Ir al contenido (pulsa Retorno)

Universitat Politècnica de Catalunya

    • Català
    • Castellano
    • English
    • LoginRegisterLog in (no UPC users)
  • mailContact Us
  • world English 
    • Català
    • Castellano
    • English
  • userLogin   
      LoginRegisterLog in (no UPC users)

UPCommons. Global access to UPC knowledge

57.065 UPC E-Prints
You are here:
View Item 
  •   DSpace Home
  • E-prints
  • Departaments
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
  • Articles de revista
  • View Item
  •   DSpace Home
  • E-prints
  • Departaments
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
  • Articles de revista
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Bioactivation of calcium deficient hydroxyapatite with foamed gelatin gel. A new injectable self-setting bone analogue

Thumbnail
View/Open
art%3A10.1007%2Fs10856-013-5071-6.pdf (2,371Mb) (Restricted access)   Request copy 

Què és aquest botó?

Aquest botó permet demanar una còpia d'un document restringit a l'autor. Es mostra quan:

  • Disposem del correu electrònic de l'autor
  • El document té una mida inferior a 20 Mb
  • Es tracta d'un document d'accés restringit per decisió de l'autor o d'un document d'accés restringit per política de l'editorial
Share:
 
 
10.1007/s10856-013-5071-6
 
  View Usage Statistics
Cita com:
hdl:2117/22962

Show full item record
Dessi, Mariagemiliana
Alvarez Perez, Marco Antonio
Santis, Roberto de
Ginebra Molins, Maria PauMés informacióMés informacióMés informació
Planell Estany, Josep AntonMés informacióMés informació
Ambrosio, Luigi
Document typeArticle
Defense date2014-02
Rights accessRestricted access - publisher's policy
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
An alternative approach to bone repair for less invasive surgical techniques, involves the development of biomaterials directly injectable into the injury sites and able to replicate a spatially organized platform with features of bone tissue. Here, the preparation and characterization of an innovative injectable bone analogue made of calcium deficient hydroxyapatite and foamed gelatin is presented. The biopolymer features and the cement self-setting reaction were investigated by rheological analysis. The porous architecture, the evolution of surface morphology and the grains dimension were analyzed with electron microscopy (SEM/ESEM/TEM). The physico-chemical properties were characterized by X-ray diffraction and FTIR analysis. Moreover, an injection test was carried out to prove the positive effect of gelatin on the flow ensuing that cement is fully injectable. The cement mechanical properties are adequate to function as temporary substrate for bone tissue regeneration. Furthermore, MG63 cells and bone marrow-derived human mesenchymal stem cells (hMSCs) were able to migrate and proliferate inside the pores, and hMSCs differentiated to the osteoblastic phenotype. The results are paving the way for an injectable bone substitute with properties that mimic natural bone tissue allowing the successful use as bone filler for craniofacial and orthopedic reconstructions in regenerative medicine.
CitationDessi, M. [et al.]. Bioactivation of calcium deficient hydroxyapatite with foamed gelatin gel. A new injectable self-setting bone analogue. "Journal of materials science. Materials in medicine", Febrer 2014, vol. 25, núm. 2, p. 283-295. 
URIhttp://hdl.handle.net/2117/22962
DOI10.1007/s10856-013-5071-6
ISSN0957-4530
Collections
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [961]
  • BBT - Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [364]
Share:
 
  View Usage Statistics

Show full item record

FilesDescriptionSizeFormatView
art%3A10.1007%2Fs10856-013-5071-6.pdfBlocked2,371MbPDFRestricted access

Browse

This CollectionBy Issue DateAuthorsOther contributionsTitlesSubjectsThis repositoryCommunities & CollectionsBy Issue DateAuthorsOther contributionsTitlesSubjects

© UPC Obrir en finestra nova . Servei de Biblioteques, Publicacions i Arxius

info.biblioteques@upc.edu

  • About This Repository
  • Contact Us
  • Send Feedback
  • Inici de la pàgina