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Increasing avß3 selectivity of the anti-angiogenic drug cilengitide by N-methylation
dc.contributor.author | Mas Moruno, Carlos |
dc.contributor.author | Beck, J.G. |
dc.contributor.author | Doedens, L. |
dc.contributor.author | Frank, A.O. |
dc.contributor.author | Marinelli, L. |
dc.contributor.author | Cosconati, S. |
dc.contributor.author | Novellino, E. |
dc.contributor.author | Kessler, H. |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2014-04-30T11:31:27Z |
dc.date.created | 2011 |
dc.date.issued | 2011 |
dc.identifier.citation | Mas-Moruno, C. [et al.]. Increasing avß3 selectivity of the anti-angiogenic drug cilengitide by N-methylation. "Angewandte chemie. International edition", 2011, vol. 50, núm. 40, p. 9496-9500. |
dc.identifier.issn | 1433-7851 |
dc.identifier.uri | http://hdl.handle.net/2117/22785 |
dc.description.abstract | Thumbnail image of graphical abstract A subtle change: Structural changes upon amide bond methylation improve the selectivity of the anti-angiogenic drug Cilengitide, which after N-methylation at distinct positions discriminates between the closely related pro-angiogenic integrins avß3 and avß5 (see scheme). |
dc.format.extent | 5 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials |
dc.subject.lcsh | Drugs--Design |
dc.subject.other | conformational studies |
dc.subject.other | cyclic peptides |
dc.subject.other | integrin |
dc.subject.other | N-methylation |
dc.subject.other | receptor selectivity |
dc.title | Increasing avß3 selectivity of the anti-angiogenic drug cilengitide by N-methylation |
dc.type | Article |
dc.subject.lemac | Medicaments -- Disseny |
dc.identifier.doi | 10.1002/anie.201102971 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/anie.201102971/abstract |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 13619184 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Mas-Moruno, C.; Beck, J.G.; Doedens, L.; Frank, A.O.; Marinelli, L.; Cosconati, S.; Novellino, E.; Kessler, H. |
local.citation.publicationName | Angewandte chemie. International edition |
local.citation.volume | 50 |
local.citation.number | 40 |
local.citation.startingPage | 9496 |
local.citation.endingPage | 9500 |
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