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dc.contributor.authorKnappe, T.A.
dc.contributor.authorManzenrieder, F.
dc.contributor.authorMas Moruno, Carlos
dc.contributor.authorLinne, U.
dc.contributor.authorSasse, F.
dc.contributor.authorKessler, H.
dc.contributor.authorXie, X.
dc.contributor.authorMarahiel, M.A.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2014-04-30T11:26:41Z
dc.date.created2011
dc.date.issued2011
dc.identifier.citationKnappe, T.A. [et al.]. Introducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist.. "Angewandte chemie. International edition", 2011, vol. 50, núm. 37, p. 8714-8717.
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/2117/22784
dc.description.abstractThumbnail image of graphical abstract Tightening the noose: Lasso peptides are a class of stable bacterial peptides with unique characteristics that encourage their application in drug design. Epitope grafting of the integrin binding motif RGD onto the lasso structure of microcin J25 converts the knotted peptide into a nanomolar integrin antagonist (see picture). Engineered lasso peptides can therefore be used for pharmacophore presentation.
dc.format.extent4 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshPeptides
dc.subject.lcshDrugs--Design
dc.subject.otherdrug design
dc.subject.otherepitope grafting
dc.subject.otherintegrin inhibitors
dc.subject.otherlasso peptides
dc.subject.othermolecular scaffolds
dc.titleIntroducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist.
dc.typeArticle
dc.subject.lemacPèptids
dc.subject.lemacMedicaments -- Disseny
dc.identifier.doi10.1002/anie.201102190
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201102190/abstract
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac13618817
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorKnappe, T.A.; Manzenrieder, F.; Mas-Moruno, C.; Linne, U.; Sasse, F.; Kessler, H.; Xie, X.; Marahiel, M.A.
local.citation.publicationNameAngewandte chemie. International edition
local.citation.volume50
local.citation.number37
local.citation.startingPage8714
local.citation.endingPage8717


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