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Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin avß3-selective cyclic RGD peptides

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10.1002/jbm.a.34303
 
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hdl:2117/22773

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Mas Moruno, CarlosMés informacióMés informacióMés informació
Dorfner, Petra M.
Manzenrieder, Florian
Neubauer, Stefanie
Reuning, Ute
Burgkart, Rainer
Kessler, Horst
Document typeArticle
Defense date2013
Rights accessRestricted access - publisher's policy
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
It is well known that functionalization of surfaces with cell adhesive peptides mimicking the integrin binding motif of extracellular matrix proteins is a feasible approach to improve osseointegration of implant materials. Also, modi- fication of the surface properties of the material (e.g., rough- ness) strongly influences cell behavior. However, these two approaches are rarely studied together. This study addressed the hypothesis that the combination of peptide functionaliza- tion and surface roughness will have an enhancing effect on the adhesion process of osteoblasts. To test this hypothesis, a series of a v b 3-selective cyclic RGD peptides were prepared and immobilized on trimmed ( S a ¼ 0.74 l m, smooth) and sandblasted ( S a ¼ 3.24 l m, rough) Ti6Al4V disks. Effects of these surface modifications were evaluated with respect to integrin a v b 3-mediated adhesive capacity, cell morphology, and spreading of primary human osteoblasts. After 3 h of incubation, osteoblasts adhered more strongly on sand- blasted than on trimmed noncoated Ti6Al4V surfaces. Their attachment efficiency was further enhanced in the presence of RGD peptides. However, peptide functionalization had a relatively stronger impact on osteoblast attachment on trimmed surfaces compared with sandblasted surfaces. Cell morphology after 3 h of culture was exclusively altered by surface topography. RGD coating was critical for osteoblast spreading on both trimmed and sandblasted materials after 1 h of incubation but it showed almost negligible effects after 3 h. The results of this study provide evidence that the alli- ance of RGD coating and surface topography on Ti6Al4V pos- itively influences osteoblast adhesion and spreading, especially at very early adhesion times
CitationMas-Moruno, C. [et al.]. Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin avß3-selective cyclic RGD peptides. "Journal of biomedical materials research. Part A", 2013, vol. 101, núm. 1, p. 87-97. 
URIhttp://hdl.handle.net/2117/22773
DOI10.1002/jbm.a.34303
ISSN1549-3296
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/jbm.a.34303/abstract
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