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dc.contributor.authorMedina Sánchez, Mariana
dc.contributor.authorMiserere, Sandrine
dc.contributor.authorMorales Narváez, Eden
dc.contributor.authorMerkoçi, Arben
dc.date.accessioned2014-04-24T09:23:54Z
dc.date.created2014-04-15
dc.date.issued2014-04-15
dc.identifier.citationMedina, M. [et al.]. On-chip magneto-immunoassay for Alzheimer's biomarker electrochemical detection by using quantum dots as labels. "Biosensors and bioelectronics", 15 Abril 2014, vol. 54, núm. 1, p. 279-284.
dc.identifier.issn0956-5663
dc.identifier.urihttp://hdl.handle.net/2117/22686
dc.description.abstractElectrochemical detection of cadmium-selenide/zinc-sulfide (CdSe@ZnS) quantum dots (QDs) as labeling carriers in an assay for apolipoprotein E (ApoE) detection has been evaluated. The immunocomplex was performed by using tosylactivated magnetic beads as preconcentration platform into a flexible hybrid polydimethylsiloxane (PDMS)-polycarbonate (PC) microfluidic chip with integrated screen printed electrodes (SPE). All the immunoassay was performed in chip and in flow mode. The sensitive electrochemical detection was obtained by square wave anodic stripping voltammetry. ApoE was evaluated for its potential as biomarker for Alzheimer's disease detection, achieving a limit of detection (LOD) of ~12.5ngmL-1 with a linear range from 10 to 200ngmL-1 and high accuracy for diluted human plasma. © 2013 Elsevier B.V.
dc.format.extent6 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria electrònica
dc.subject.lcshElectrochemistry
dc.subject.lcshBiochemical markers
dc.subject.lcshAlzheimer's disease
dc.subject.otherAlzheimer biomarker
dc.subject.otherApolipoprotein E (ApoE)
dc.subject.otherElectrochemistry
dc.subject.otherMagnetic beads
dc.subject.otherMicrofluidic
dc.subject.otherQuantum dots
dc.titleOn-chip magneto-immunoassay for Alzheimer's biomarker electrochemical detection by using quantum dots as labels
dc.typeArticle
dc.subject.lemacElectroquímica
dc.subject.lemacAlzheimer, Malaltia d'
dc.identifier.doi10.1016/j.bios.2013.10.069
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0956566313007719
dc.rights.accessRestricted access - publisher's policy
drac.iddocument12968925
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/246513/EU/Nanosystems for the early Diagnosis of Neurodegenerative diseases/NADINE
dc.date.lift10000-01-01
upcommons.citation.authorMedina, M.; Miserere, S.; Morales, E.; Merkoçi, Arben
upcommons.citation.publishedtrue
upcommons.citation.publicationNameBiosensors and bioelectronics
upcommons.citation.volume54
upcommons.citation.number1
upcommons.citation.startingPage279
upcommons.citation.endingPage284


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