Mostra el registre d'ítem simple
Obstructive sleep apnea in a rat model: effects of anesthesia on autonomic evaluation from heart rate variability measures
dc.contributor.author | Jané Campos, Raimon |
dc.contributor.author | Lázaro, Jesús |
dc.contributor.author | Ruiz, Puy |
dc.contributor.author | Gil, Eduardo |
dc.contributor.author | Navajas, Daniel |
dc.contributor.author | Farré, Ramon |
dc.contributor.author | Laguna, Pablo |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial |
dc.contributor.other | Institut de Bioenginyeria de Catalunya |
dc.date.accessioned | 2014-03-14T13:14:31Z |
dc.date.created | 2013 |
dc.date.issued | 2013 |
dc.identifier.citation | Jane, R. [et al.]. Obstructive sleep apnea in a rat model: effects of anesthesia on autonomic evaluation from heart rate variability measures. A: Computing in Cardiology. "Computing in Cardiology Conference (CinC), 2013". Zaragoza: Computing in Cardiology, 2013, p. 1011-1014. |
dc.identifier.isbn | 978-1-4799-0884-4 |
dc.identifier.uri | http://hdl.handle.net/2117/22067 |
dc.description.abstract | Rat model of Obstructive Sleep Apnea (OSA) is a realistic approach for studying physiological mechanisms involved in sleep. Rats are usually anesthetized and autonomic nervous system (ANS) could be blocked. This study aimed to assess the effect of anesthesia on ANS activity during OSA episodes. Seven male SpragueDawley rats were anesthetized intraperitoneally with urethane (1 g/kg). The experiments were conducted applying airway obstructions, simulating 15s-apnea episodes for 15 minutes. Five signals were acquired: respiratory pressure and flow, Sa02, ECG and photoplethysmography (PPG). In total, 210 apnea episodes were studied. Normalized power spectrum of Pulse Rate Variability (PRV) was analyzed in the Low Frequency (LF) and High Frequency (HF) bands, for each episode in consecutive 15s intervals (before, during and after the apnea). All episodes showed changes in respiratory flow and Sa02 signal. Conversely, decreases in the amplitude fluctuations of PPG (DAP) were not observed. Normalized LF presented extremely low values during breathing (median=7,67%), suggesting inhibition of sympathetic system due to anesthetic effect. Subtle increases of LF were observed during apnea. HRV and PPG analysis during apnea could be an indirect tool to assess the effect and deep of anesthesia. |
dc.format.extent | 4 p. |
dc.language.iso | eng |
dc.publisher | Computing in Cardiology |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
dc.subject.lcsh | Sleep apnea syndromes -- Animal models |
dc.subject.other | Sleep Apnea |
dc.subject.other | Anestesia |
dc.subject.other | Heart rate variability |
dc.subject.other | Rat model |
dc.title | Obstructive sleep apnea in a rat model: effects of anesthesia on autonomic evaluation from heart rate variability measures |
dc.type | Conference report |
dc.subject.lemac | Trastorns del son |
dc.contributor.group | Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://ieeexplore.ieee.org/xpl/articleDetails.jsp?tp=&arnumber=6713551&ranges%3D2013_2013_p_Publication_Year%26queryText%3DJan%C3%A9+R |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 13392372 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Jane, R.; Lázaro, J.; Ruiz, P.; Gil, E.; Navajas, D.; Farré, R.; Laguna, P. |
local.citation.contributor | Computing in Cardiology |
local.citation.pubplace | Zaragoza |
local.citation.publicationName | Computing in Cardiology Conference (CinC), 2013 |
local.citation.startingPage | 1011 |
local.citation.endingPage | 1014 |