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dc.contributor.authorSerafini Immich, Ana
dc.contributor.authorLis Arias, Manuel José
dc.contributor.authorCarreras Molina, Núria
dc.contributor.authorBoemo, Rafael Luis
dc.contributor.authorTornero García, José Antonio
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Resistència de Materials i Estructures a l'Enginyeria
dc.contributor.otherUniversitat Politècnica de Catalunya. Institut d'Investigació Tèxtil i Cooperació Industrial de Terrassa
dc.identifier.citationSerafini, A. [et al.]. Drug delivery systems using sandwich configurations of electrospun poly(lactic acid) nanofiber membranes and ibuprofen. "Materials science and engineering C. Biomimetic and supramolecular systems", Octubre 2013, vol. 33, núm. 7, p. 4002-4008.
dc.description.abstractThe primary advantages of electrospun membranes include the ability to obtain very thin fibers that are on the order of magnitude of several nanometers with a considerable superficial area and the possibility for these membranes to be manipulated and processed for many different applications. The purpose of this study is to evaluate and quantify the transport mechanisms that control the release of drugs from polymer-based sandwich membranes produced using the electrospinning processes. These electrospun membranes were composed of poly(lactic acid) (PLA) because it is one of the most promising biodegradable polymers due to its mechanical properties, thermoplastic processability and biological properties, such as its biocompatibility and biodegradability. The transport mechanism that controls the drug delivery was evaluated via the release kinetics of a bioactive agent in physiological serum, which was used as a corporal fluid simulation. To describe the delivery process, mathematical models, such as the Power Law, the classical Higuchi equation and an approach to Fick's Second Law were used. Using the applied mathematical models, it is possible to conclude that control over the release of the drug is significantly dependent on the thickness of the membrane rather than the concentration of the drug.
dc.format.extent7 p.
dc.subjectÀrees temàtiques de la UPC::Enginyeria tèxtil ::Fibres tèxtils::Fibres sintètiques
dc.subject.otherDrug delivery
dc.subject.otherPoly(lactic acid)
dc.titleDrug delivery systems using sandwich configurations of electrospun poly(lactic acid) nanofiber membranes and ibuprofen
dc.subject.lemacMaterials nanoestructurals
dc.subject.lemacFibres tèxtils sintètiques
dc.subject.lemacPolímers -- Propietats elèctriques
dc.contributor.groupUniversitat Politècnica de Catalunya. POLQUITEX - Materials Polimérics i Química Téxtil
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - publisher's policy
dc.description.versionPostprint (published version)
local.citation.authorSerafini, A.; Lis, M.; Carreras, N.; Boemo, R.L.; Tornero, J.
local.citation.publicationNameMaterials science and engineering C. Biomimetic and supramolecular systems

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