Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)

Paoletti, Iole; De Gregorio, Vicenza; Baroni, Adone; Tufano, Maria Antonieta; Donnarumma, Giovanna; Pérez González, Juan Jesús

doi:10.1007/s10753-013-9670-7

dc.contributor.author	Paoletti, Iole
dc.contributor.author	De Gregorio, Vicenza
dc.contributor.author	Baroni, Adone
dc.contributor.author	Tufano, Maria Antonieta
dc.contributor.author	Donnarumma, Giovanna
dc.contributor.author	Pérez González, Juan Jesús
dc.contributor.other	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned	2014-01-20T11:41:34Z
dc.date.created	2013-12-02
dc.date.issued	2013-12-02
dc.identifier.citation	Paoletti, I. [et al.]. Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat). "Inflammation", 02 Desembre 2013, vol. 36, núm. 6, p. 1316-1326.
dc.identifier.issn	0360-3997
dc.identifier.uri	http://hdl.handle.net/2117/21281
dc.description.abstract	Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120- coating protein, appears to be bene fi cial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN- γ and TNF- α -NHEK activated cells. Moreover, we analysed the interference of PT and its analogues through STAT-3 activation. Our results show that the analogues tested exhibit the bene fi cial biol- ogical effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptido- mimetics act directly, by reducing proin fl ammatory responses. Its reduction appears to be important for therapeutic approach in psoriasis pathogenesis
dc.format.extent	11 p.
dc.language.iso	eng
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria química
dc.subject.lcsh	Peptides
dc.subject.lcsh	Psoriasis
dc.subject.other	peptide T
dc.subject.other	amygdalin analogues
dc.subject.other	NHEK cells
dc.subject.other	psoriasis
dc.title	Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)
dc.type	Article
dc.subject.lemac	Pèptids
dc.subject.lemac	Psoriasi
dc.contributor.group	Universitat Politècnica de Catalunya. ENGMOL - Enginyeria Molecular
dc.identifier.doi	10.1007/s10753-013-9670-7
dc.description.peerreviewed	Peer Reviewed
dc.relation.publisherversion	http://link.springer.com/article/10.1007%2Fs10753-013-9670-7
dc.rights.access	Restricted access - publisher's policy
local.identifier.drac	12942633
dc.description.version	Postprint (published version)
dc.date.lift	10000-01-01
local.citation.author	Paoletti, I.; De Gregorio, V.; Baroni, A.; Tufano, M.; Donnarumma, G.; Perez, J.
local.citation.publicationName	Inflammation
local.citation.volume	36
local.citation.number	6
local.citation.startingPage	1316
local.citation.endingPage	1326