| dc.contributor.author | Paoletti, Iole |
| dc.contributor.author | De Gregorio, Vicenza |
| dc.contributor.author | Baroni, Adone |
| dc.contributor.author | Tufano, Maria Antonieta |
| dc.contributor.author | Donnarumma, Giovanna |
| dc.contributor.author | Pérez González, Juan Jesús |
| dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
| dc.date.accessioned | 2014-01-20T11:41:34Z |
| dc.date.created | 2013-12-02 |
| dc.date.issued | 2013-12-02 |
| dc.identifier.citation | Paoletti, I. [et al.]. Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat). "Inflammation", 02 Desembre 2013, vol. 36, núm. 6, p. 1316-1326. |
| dc.identifier.issn | 0360-3997 |
| dc.identifier.uri | http://hdl.handle.net/2117/21281 |
| dc.description.abstract | Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120-
coating protein, appears to be bene
fi
cial in the treatment of psoriasis. Our previous investigations
suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis.
The aim of this study was to explore the effects of PT and the peptidomimetic natural products,
Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-
γ
and TNF-
α
-NHEK activated cells. Moreover, we analysed the interference of PT and its analogues
through STAT-3 activation. Our results show that the analogues tested exhibit the bene
fi
cial biol-
ogical effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptido-
mimetics act directly, by reducing proin
fl
ammatory responses. Its reduction appears to be important
for therapeutic approach in psoriasis pathogenesis |
| dc.format.extent | 11 p. |
| dc.language.iso | eng |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
| dc.subject.lcsh | Peptides |
| dc.subject.lcsh | Psoriasis |
| dc.subject.other | peptide T |
| dc.subject.other | amygdalin analogues |
| dc.subject.other | NHEK cells |
| dc.subject.other | psoriasis |
| dc.title | Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat) |
| dc.type | Article |
| dc.subject.lemac | Pèptids |
| dc.subject.lemac | Psoriasi |
| dc.contributor.group | Universitat Politècnica de Catalunya. ENGMOL - Enginyeria Molecular |
| dc.identifier.doi | 10.1007/s10753-013-9670-7 |
| dc.description.peerreviewed | Peer Reviewed |
| dc.relation.publisherversion | http://link.springer.com/article/10.1007%2Fs10753-013-9670-7 |
| dc.rights.access | Restricted access - publisher's policy |
| local.identifier.drac | 12942633 |
| dc.description.version | Postprint (published version) |
| dc.date.lift | 10000-01-01 |
| local.citation.author | Paoletti, I.; De Gregorio, V.; Baroni, A.; Tufano, M.; Donnarumma, G.; Perez, J. |
| local.citation.publicationName | Inflammation |
| local.citation.volume | 36 |
| local.citation.number | 6 |
| local.citation.startingPage | 1316 |
| local.citation.endingPage | 1326 |
