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dc.contributor.authorPaoletti, Iole
dc.contributor.authorDe Gregorio, Vicenza
dc.contributor.authorBaroni, Adone
dc.contributor.authorTufano, Maria Antonieta
dc.contributor.authorDonnarumma, Giovanna
dc.contributor.authorPérez González, Juan Jesús
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2014-01-20T11:41:34Z
dc.date.created2013-12-02
dc.date.issued2013-12-02
dc.identifier.citationPaoletti, I. [et al.]. Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat). "Inflammation", 02 Desembre 2013, vol. 36, núm. 6, p. 1316-1326.
dc.identifier.issn0360-3997
dc.identifier.urihttp://hdl.handle.net/2117/21281
dc.description.abstractPeptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120- coating protein, appears to be bene fi cial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN- γ and TNF- α -NHEK activated cells. Moreover, we analysed the interference of PT and its analogues through STAT-3 activation. Our results show that the analogues tested exhibit the bene fi cial biol- ogical effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptido- mimetics act directly, by reducing proin fl ammatory responses. Its reduction appears to be important for therapeutic approach in psoriasis pathogenesis
dc.format.extent11 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshPeptides
dc.subject.lcshPsoriasis
dc.subject.otherpeptide T
dc.subject.otheramygdalin analogues
dc.subject.otherNHEK cells
dc.subject.otherpsoriasis
dc.titleAmygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)
dc.typeArticle
dc.subject.lemacPèptids
dc.subject.lemacPsoriasi
dc.contributor.groupUniversitat Politècnica de Catalunya. ENGMOL - Enginyeria Molecular
dc.identifier.doi10.1007/s10753-013-9670-7
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://link.springer.com/article/10.1007%2Fs10753-013-9670-7
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac12942633
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorPaoletti, I.; De Gregorio, V.; Baroni, A.; Tufano, M.; Donnarumma, G.; Perez, J.
local.citation.publicationNameInflammation
local.citation.volume36
local.citation.number6
local.citation.startingPage1316
local.citation.endingPage1326


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain