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dc.contributor.authorGana, Inès
dc.contributor.authorBarrio Casado, María del
dc.contributor.authorDo, Bernard
dc.contributor.authorTamarit Mur, José Luis
dc.contributor.authorCéolin, René
dc.contributor.authorRietveld, Ivo B.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
dc.date.accessioned2014-01-19T12:57:06Z
dc.date.created2013-11-18
dc.date.issued2013-11-18
dc.identifier.citationGana, I. [et al.]. Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III. "International journal of pharmaceutics", 18 Novembre 2013, vol. 456, núm. 2, p. 480-488.
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/2117/21276
dc.description.abstracttUnderstanding the phase behavior of an active pharmaceutical ingredient in a drug formulation isrequired to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in amarketed product. Benzocaine is known to possess three crystalline polymorphs, but their stability hier-archy has so far not been determined. A topological method and direct calorimetric measurements underpressure have been used to construct the topological pressure–temperature diagram of the phase rela-tionships between the solid phases II and III, the liquid, and the vapor phase. In the process, the transitiontemperature between solid phases III and II and its enthalpy change have been determined. Solid phaseII, which has the highest melting point, is the more stable phase under ambient conditions in this phasediagram. Surprisingly, solid phase I has not been observed during the study, even though the scarce lit-erature data on its thermal behavior appear to indicate that it might be the most stable one of the threesolid phases.
dc.format.extent9 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Farmacologia
dc.subjectÀrees temàtiques de la UPC::Física::Termodinàmica
dc.subject.lcshPharmaceutical industry
dc.subject.lcshThermodynamics
dc.subject.otherPhase diagram
dc.subject.otherPhysical stability
dc.subject.otherPolymorphism
dc.subject.otherPressure
dc.subject.otherThermodynamics
dc.subject.otherX-ray powder diffraction
dc.titleBenzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III
dc.typeArticle
dc.subject.lemacIndústria farmacèutica
dc.subject.lemacTermodinàmica
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.identifier.doi10.1016/j.ijpharm.2013.08.031
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0378517313007643
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac12898777
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorGana, I.; Del Barrio, M.; Do, B.; Tamarit, J.; Céolin, R.; Rietveld, I.R.
local.citation.publicationNameInternational journal of pharmaceutics
local.citation.volume456
local.citation.number2
local.citation.startingPage480
local.citation.endingPage488


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain