Injectable collagen/alpha-tricalcium phosphate cement: collagen-mineral phase interactions and cell response
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Realitzat a/ambCentro de Investigación Biomédica en Red. Bioingeniería, Biomateriales y Nanomedicina; Center for Research in NanoEngineering (CRNE)
Tipus de documentArticle
Data publicació2013-02
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Abstract
A bone inspired material was obtained by
incorporating collagen in the liquid phase of an
a
-trical-
cium phosphate cement, either in solubilized or in fibrilized
form. This material was able to set in situ, giving rise to a
calcium deficient hydroxyapatite (CDHA)/collagen com-
posite. The morphology and distribution of collagen in the
composite was shown to be strongly affected by the col-
lagen pre-treatment. The interactions between collagen and
the inorganic phase were assessed by FTIR. A red shift of
the amide I band was indicative of calcium chelation by the
collagen carbonyl groups. The rate of CDHA formation
was not affected when diluted collagen solutions (1 mg/ml)
were used, whereas injectability improved. The presence of
solubilized collagen, even in low amount (1 %), increased
cell adhesion and proliferation on the composites. Still in
the absence of osteogenic medium, significant ALP activity
was detected both in the inorganic and the collagen-con-
taining cements. The maximum ALP activity was advanced
in the collagen-containing cement as compared to the
inorganic cement.
CitacióPerez, R.A.; Ginebra, M.P. Injectable collagen/alpha-tricalcium phosphate cement: collagen-mineral phase interactions and cell response. "Journal of materials science. Materials in medicine", Febrer 2013, vol. 24, núm. 2, p. 381-393.
ISSN0957-4530
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art%3A10.1007%2Fs10856-012-4799-8.pdf | 1,116Mb | Accés restringit |