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dc.contributor.authorMiranda, Ronald Alexander
dc.contributor.authorFinocchio, Elisabetta
dc.contributor.authorLlorca Piqué, Jordi
dc.contributor.authorMedina, Francisco
dc.contributor.authorRamis, Gianguido
dc.contributor.authorSueiras, Jesus Eduardo
dc.contributor.authorSegarra, A.M.
dc.contributor.otherUniversitat Politècnica de Catalunya. Institut de Tècniques Energètiques
dc.date.accessioned2013-12-04T12:21:17Z
dc.date.created2013-10-07
dc.date.issued2013-10-07
dc.identifier.citationMiranda, R.A. [et al.]. Synthesis and characterization of poly-l-leucine initialized and immobilized by rehydrated hydrotalcite: Understanding stability and the nature of interaction. "Physical chemistry chemical physics", 07 Octubre 2013, vol. 15, núm. 37, p. 15645-15659.
dc.identifier.issn1463-9076
dc.identifier.urihttp://hdl.handle.net/2117/20909
dc.description.abstractPLLs were synthesized by the ring-opening polycondensation (ROP) method using α-L-leucine N-carboxyanhydride (NCA) and initialized by triethylamine (Et3N), water or rehydrated hydrotalcite (HTrus). The role of temperature, different initiators and water in ROP was further investigated. In general, the initiators used in the polymerization reaction lead to PLL alpha-helical chains containing 5–40 monomers with NCA endgroups via a monomer-activated mechanism. However, the water has a twofold effect on ROP, as both a nucleophile and a base, which involves competition between two different types of initiating mechanisms (nucleophilic attack or deprotonation of the NCA monomer) in the polymerization reaction. This competition provides as a main product NCA endgroups with an alpha-helical structure and leads to the formation of the PLL cyclic-chains and beta-sheet structures which reduce the polymer Mw and the PD of the polypeptide. Furthermore, the water can hydrolyze the NCA endgroups resulting in PLL alpha-helical chains that contain living groups as the main product. On the other hand, the HTrus presents a double role: as both an initiator and a support. The polymers synthesized in the presence of HTrus presented a HT-carboxylate endgroup. The PLLs immobilized in HTrus through an anion-exchange method performed for just 30 minutes presented the PLL immobilized in the interlayer space of the HTrus. The PLL chains of the immobilized counterpart are stabilized by H-bonding with the M–OH of the HT structure. All the polypeptides and biohybrid materials synthesized have been characterized using different techniques (EA, ICP, XRD, Raman, MALDI-TOF, ESI-TOF, FT-IR at increasing temperatures, TG/DT analyses and TEM).
dc.format.extent15 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química::Química física
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials::Materials plàstics i polímers
dc.subject.lcshPolymers
dc.subject.lcshPolymerization
dc.titleSynthesis and characterization of poly-l-leucine initialized and immobilized by rehydrated hydrotalcite: Understanding stability and the nature of interaction
dc.typeArticle
dc.subject.lemacPolímers
dc.subject.lemacPolimerització -- Síntesi
dc.contributor.groupUniversitat Politècnica de Catalunya. GREENER - Grup de recerca d'estudis energètics i de les radiacions
dc.identifier.doi10.1039/c3cp52187g
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac12792115
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorMiranda, R.A.; Finocchio, E.; Llorca, J.; Medina, F.; Ramis, G.; Sueiras, J.E.; Segarra, A.
local.citation.publicationNamePhysical chemistry chemical physics
local.citation.volume15
local.citation.number37
local.citation.startingPage15645
local.citation.endingPage15659


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Salvo que se indique lo contrario, los contenidos de esta obra estan sujetos a la licencia de Creative Commons : Reconocimiento-NoComercial-SinObraDerivada 3.0 España