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The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche.

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10.1016/j.biomaterials.2012.12.001
 
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hdl:2117/20906

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Álvarez, Zaída
Mateos Timoneda, Miguel ÁngelMés informació
Hyroššová, Petra Hyroššová
Castaño Linares, ÓscarMés informació
Planell Estany, Josep AntonMés informacióMés informació
Perales, José C.
Engel López, ElisabethMés informacióMés informacióMés informació
Alcántara, Soledad
Tipo de documentoArtículo
Fecha de publicación2013-03-06
Condiciones de accesoAcceso restringido por política de la editorial
Attribution-NonCommercial-NoDerivs 3.0 Spain
Salvo que se indique lo contrario, los contenidos de esta obra estan sujetos a la licencia de Creative Commons : Reconocimiento-NoComercial-SinObraDerivada 3.0 España
Resumen
To develop tissue engineering strategies useful for repairing damage in the central nervous system (CNS) it is essential to design scaffolds that emulate the NSC niche and its tight control of neural cell genesis, growth, and differentiation. In this study we tested two types of poly l/dl lactic acid (PLA95/5 and PLA70/30), a biodegradable material permissive for neural cell adhesion and growth, as materials for nerve regeneration. Both PLA were slightly hydrophobic and negatively charged but differed in crystallinity, stiffness and degradation rate. PLA95/5 films were highly crystalline, stiff (GPa), and did not degrade significantly in the one-month period analyzed in culture. In contrast, PLA70/30 films were more amorphous, softer (MPa) and degraded faster, releasing significant amounts of lactate into the culture medium. PLA70/30 performs better than PLA95/5 for primary cortical neural cell adhesion, proliferation and differentiation, maintaining the pools of neuronal and glial progenitor cells in vitro. l-lactate in the medium recapitulated PLA70/30's maintenance of neuronal restricted progenitors but did not sustain bipotential or glial restricted progenitors in the cultures, as occurred when neural cells were grown on PLA70/30. Our results suggest that PLA70/30 may mimic some of the physical and biochemical characteristics of the NSC niche. Its mechanical and surface properties may act synergistically in the modulation of bipotential and glial restricted progenitor phenotypes, while it is l-lactate, either added to the medium or released by the film that drives the maintenance of neuronal restricted progenitor cell phenotypes.
CitaciónÁlvarez, Z. [et al.]. The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche.. "Biomaterials", 06 Març 2013, vol. 34, núm. 9, p. 2221-2233. 
URIhttp://hdl.handle.net/2117/20906
DOI10.1016/j.biomaterials.2012.12.001
ISSN0142-9612
Versión del editorhttp://www.sciencedirect.com/science/article/pii/S0142961212013671#
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  • IBEC - Institute for Bioengineering of Catalonia - Articles de revista [50]
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [961]
  • BBT - Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [369]
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