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dc.contributor.authorPerez, R.A.
dc.contributor.authorAltankov, George Petrov
dc.contributor.authorJorge Herrero, E.
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2013-11-25T11:50:47Z
dc.date.created2013-05
dc.date.issued2013-05
dc.identifier.citationPerez, R.A. [et al.]. Micro- and nanostructured hydroxyapatitecollagen microcarriers for bone tissue-engineering applications. "Journal of tissue engineering and regenerative medicine", Maig 2013, vol. 7, núm. 5, p. 353-361.
dc.identifier.issn1932-6254
dc.identifier.urihttp://hdl.handle.net/2117/20712
dc.description.abstractNovel hydroxyapatite (HA)–collagen microcarriers (MCs) with different micro/nanostructures were developed for bone tissue-engineering applications. The MCs were fabricated via calcium phosphate cement (CPC) emulsion in oil. Collagen incorporation in the liquid phase of the CPC resulted in higher MC sphericity. The MCs consisted of a porous network of entangled hydroxyapatite crystals, formed as a result of the CPC setting reaction. The addition of collagen to the MCs, even in an amount as small as 0.8 wt%, resulted in an improved interaction with osteoblast-like Saos-2 cells. The micro/nanostructure and the surface texture of the MCs were further tailored by modifying the initial particle size of the CPC. A synergistic effect between the presence of collagen and the nanosized HA crystals was found, resulting in significantly enhanced alkaline phosphatase activity on the collagen-containing nanosized HA MCs
dc.format.extent9 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshBone regeneration
dc.subject.lcshCalcium phosphate
dc.subject.otherhydroxyapatite
dc.subject.othermicrocarrier
dc.subject.othercollagen
dc.subject.othercalcium phosphate cement
dc.subject.otherbone regeneration
dc.subject.othercell response
dc.titleMicro- and nanostructured hydroxyapatitecollagen microcarriers for bone tissue-engineering applications
dc.typeArticle
dc.subject.lemacOssos -- Regeneració
dc.subject.lemacFosfat de calci
dc.subject.lemacCiments ossis
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1002/term.530
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac12667240
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorPerez, R.A.; Altankov, G.; Jorge-Herrero, E.; Ginebra, M.P.
local.citation.publicationNameJournal of tissue engineering and regenerative medicine
local.citation.volume7
local.citation.number5
local.citation.startingPage353
local.citation.endingPage361


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain