Hierarchically engineered fibrous scaffolds for bone regeneration

Document typeArticle
Defense date2013-08-28
Rights accessOpen Access
Abstract
Surface properties of biomaterials play a major role in the governing of cell
functionalities. It is well known that mechanical, chemical and nanotopo-
graphic cues, for example, influence cell proliferation and differentiation.
Here, we present a novel coating protocol to produce hierarchicallyengineered
fibrous scaffolds with tailorable surface characteristics, which mimic bone
extracellular matrix. Based on the sol–gel method and a succession of surface
treatments, hollow electrospun polylactic acid fibres were coated with a
silicon–calcium–phosphate bioactive organic–inorganic glass. Compared
with pure polymeric fibres that showed a completely smooth surface, the
coated fibres exhibited a nanostructured topography and greater roughness.
They also showed improved hydrophilic properties and a Young’s modulus
sixfold higher than non-coated ones, while remaining fully flexible and easy
to handle. Rat mesenchymal stem cells cultured on these fibres showed
great cellular spreading and interactions with the material. This protocol can
be transferred to other structures and glasses, allowing the fabrication of var-
ious materials with well-defined features. This novel approach represents
therefore a valuable improvement in the production of artificial matrices
able to direct stem cell fate through physical and chemical interactions
CitationSachot, N. [et al.]. Hierarchically engineered fibrous scaffolds for bone regeneration. "Journal of the Royal Society Interface", 28 Agost 2013, vol. 10, núm. 88, p. 1-5.
ISSN1742-5689
Publisher versionhttp://rsif.royalsocietypublishing.org/content/10/88/20130684
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