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dc.contributor.authorVallmitjana Lees, Alexander
dc.contributor.authorHove-Madsen, Leif
dc.contributor.authorBarriga, Montserrat
dc.contributor.authorBenítez Iglesias, Raúl
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.identifier.citationVallmitjana, A. [et al.]. Multilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes. A: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. "35th Annual International Conference of the IEEE EMBS". Osaka: Institute of Electrical and Electronics Engineers (IEEE), 2013, p. 6514-6517.
dc.description.abstractWe present an automatic method to characterize calcium activity in a culture of cardiac cells from a sequence of microscopy fluorescence images. The approach quantifies both the response of each individual cell in the culture to external field stimulation and the propagation properties of calcium wave-fronts, thus providing complementary information at different physiological levels. The technique classifies the response of each cell as regular or irregular based on a set of dynamical and morphological features of the calcium transients. Isochronal maps were constructed from the local activation times across the culture, and the front propagation was classified as planar or non-planar. The method has been applied to a set of 35 experiments, and the results indicate a significative connection between irregular behavior at the single-cell level and irregular front propagation
dc.format.extent4 p.
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)
dc.subjectÀrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
dc.subject.lcshHeart -- Diseases -- Cytopatology
dc.subject.otherBiomedical signal processing
dc.subject.othercardiac physiology
dc.subject.othercell dynamics
dc.titleMultilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes
dc.typeConference report
dc.subject.lemacCor -- Malalties -- Aspectes moleculars
dc.contributor.groupUniversitat Politècnica de Catalunya. NOLIN - Física No-Lineal i Sistemes Fora de l'Equilibri
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - publisher's policy
dc.description.versionPostprint (published version)
local.citation.authorVallmitjana, A.; Hove-Madsen, L.; Barriga, M.; Benitez, R.
local.citation.contributorAnnual International Conference of the IEEE Engineering in Medicine and Biology Society
local.citation.publicationName35th Annual International Conference of the IEEE EMBS

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