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Time of progression to osteopenia/osteoporosis in chronically HIV-infected patients: screening DXA scan
dc.contributor.author | Negredo, Eugènia |
dc.contributor.author | Bonjoch, Anna |
dc.contributor.author | Gómez Mateu, Moisés |
dc.contributor.author | Estany, Carla |
dc.contributor.author | Puig, Jordi |
dc.contributor.author | Pérez Álvarez, Nuria |
dc.contributor.author | Rosales, Joaquim |
dc.contributor.author | di Gregorio, Silvana |
dc.contributor.author | del Rio, Luis |
dc.contributor.author | Gómez Melis, Guadalupe |
dc.contributor.author | Clotet, Bonaventura |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa |
dc.date.accessioned | 2013-07-02T10:18:04Z |
dc.date.available | 2013-07-02T10:18:04Z |
dc.date.created | 2012-10-08 |
dc.date.issued | 2012-10-08 |
dc.identifier.citation | Negredo, E. [et al.]. Time of progression to osteopenia/osteoporosis in chronically HIV-infected patients: screening DXA scan. "PLoS One", 08 Octubre 2012, vol. 7, núm. 10, p. e46031-1-e46031-9. |
dc.identifier.issn | 1932-6203 |
dc.identifier.uri | http://hdl.handle.net/2117/19758 |
dc.description.abstract | Algorithms for bone mineral density (BMD) management in HIV-infected patients are lacking. Our objective was to assess how often a dual-energy x-ray absorptiometry (DXA) scan should be performed by assessing time of progression to osteopenia/osteoporosis. Methods: All DXA scans performed between 2000 and 2009 from HIV-infected patients with at least two DXA were included. Time to an event (osteopenia and osteoporosis) was assessed using the Kaplan–Meier method. Strata (tertiles) were defined using baseline minimum T scores. Differences between strata in time to an event were compared with the log-rank test. Results: Of 391 patients (1,639 DXAs), 49.6% had osteopenia and 21.7% osteoporosis at their first DXA scan. Of the 112 (28.6%) with normal BMD, 35.7% progressed to osteopenia; median progression time was 6.7 years. These patients were stratified: “low-risk" (baseline minimum T score >−0.2 SD), “middle-risk" (between −0.2 and −0.6 SD), and “high-risk" (from −0.6 to −1 SD); median progression time to osteopenia was 8.7, >7.2, and 1.7 years, respectively (p<0.0001). Of patients with osteopenia, 23.7% progressed to osteoporosis; median progression time was >8.5 years. Progression time was >8.2 years in “low-risk" tertile (T score between −1.1 and −1.6 SD), >8.5 years in “middle-risk" (between −1.6 and −2), and 3.2 years in “high-risk" (from −2 to −2.4) (p<0.0001). Conclusions: Our results may help to define the BMD testing interval. The lowest T score tertiles would suggest recommending a subsequent DXA in 1–2 years; in the highest tertiles, ≥6 years. Early intervention in patients with bone demineralization could reduce fracture–related morbidity/mortality. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina interna |
dc.subject.lcsh | AIDS (Disease) -- Research -- Methodology |
dc.subject.other | BONE-MINERAL DENSITY |
dc.subject.other | ANTIRETROVIRAL THERAPY |
dc.subject.other | PROTEASE INHIBITORS |
dc.subject.other | HIGH PREVALENCE |
dc.subject.other | FRACTURE RISK |
dc.subject.other | OSTEOPOROSIS |
dc.subject.other | WOMEN |
dc.subject.other | DISEASE |
dc.subject.other | OSTEOCLASTOGENESIS |
dc.subject.other | OSTEOBLASTS |
dc.title | Time of progression to osteopenia/osteoporosis in chronically HIV-infected patients: screening DXA scan |
dc.type | Article |
dc.subject.lemac | Sida -- Investigació |
dc.contributor.group | Universitat Politècnica de Catalunya. GREMA - Grup de Recerca en Estadística Matemàtica i les seves Aplicacions |
dc.identifier.doi | 10.1371/journal.pone.0046031 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.ncbi.nlm.nih.gov/pubmed/23056229 |
dc.rights.access | Open Access |
local.identifier.drac | 11110706 |
dc.description.version | Postprint (published version) |
local.citation.author | Negredo, E.; Bonjoch, A.; Gomez, M.; Estany, C.; Puig, J.; Perez, N.; Rosales, J.; di Gregorio, S.; del Rio, L.; Gomez, G.; Clotet, B. |
local.citation.publicationName | PLoS One |
local.citation.volume | 7 |
local.citation.number | 10 |
local.citation.startingPage | e46031-1 |
local.citation.endingPage | e46031-9 |
dc.identifier.pmid | 23056229 |
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